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Pregled bibliografske jedinice broj: 397709

Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia


Malnar, Martina; Petek Tarnik, Iva; Košiček, Marko; Pavelin, Sanda; Titlić, Marina; Trkanjec, Zlatko; Demarin, Vida; Hećimović, Silva
Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia // Abstracts of trhe 8th Balkan Meeting on Human Genetics ; u: Paediatria Croatica 53 (2009) (S2)
Cavtat, Hvatska, 2009. str. 69-69 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 397709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia

Autori
Malnar, Martina ; Petek Tarnik, Iva ; Košiček, Marko ; Pavelin, Sanda ; Titlić, Marina ; Trkanjec, Zlatko ; Demarin, Vida ; Hećimović, Silva

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of trhe 8th Balkan Meeting on Human Genetics ; u: Paediatria Croatica 53 (2009) (S2) / - , 2009, 69-69

Skup
Balkan Meeting on Human Genetics (8 ; 2009)

Mjesto i datum
Cavtat, Hvatska, 14.-17.05.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer's disease; APP protein; Abeta peptide; biomarkers; diagnosis; neurodegeneration; tau

Sažetak
Alzheimer's disease (AD) is the leading cause of dementia with no adequate therapies and no tests that would enable accurate diagnosis of AD during lifetime. The aim of this work was to evaluate the levels of Abeta42, total-tau (t-tau), phospho181-tau (P181-tau) in the cerebrospinal fluid (CSF) and/or CSF t-tau/Abeta42 ratio as an early biomarker(s) of Alzheimer's disease. In this pilot study we analyzed CSF samples of clinically assesed AD individuals (N=12, mean age=73 years), healthy age-matched individuals (N=13, mean age=63 years) and demented patients with no certain diagnosis (N=11, mean age= 69 years). The levels of Abeta42, t-tau and P181-tau in CSF were determined using ELISA assay. Our results show that CSF-Abeta42 levels and CSF t-tau/Abeta42 ratio give 75% and 100% specificity of detecting AD cases, respectively, suggesting that the two biomarkers may be used for early and differential diagnosis of Alzheimer's disease. In agreement with previous study by Fagan et al. (2007) we found low CSF-Abeta42 levels ( 476 pg/mL) and high CSF t-tau/Abeta42 ratio ( 0.744) to be characteristic for AD cases. Among 12 clinically diagnosed AD individuals we identified three non-AD cases, while 64% (7/11) of demented individuals with no certain diagnosis were detected to have AD by the CSF analysis. Interestingly, two cases of AD were found in the age-matched control group, indicating that this test may detect non-demented and/or mildly cognitively impaired cases (MCIs) who will develop Alzheimer's disease. In summary, our pilot study supports CSF-Abeta42 and CSF t-tau/Abeta42 levels as early biomarkers of Alzheimer's disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982522-2525 - Mehanizam djelovanja kolesterola u nastanku Alzheimerove bolesti (Katušić Hećimović, Silva, MZOS ) ( POIROT)
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Demarin, Vida, MZOS ) ( POIROT)
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Trkanjec, Zlatko, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice",
Medicinski fakultet, Split


Citiraj ovu publikaciju:

Malnar, Martina; Petek Tarnik, Iva; Košiček, Marko; Pavelin, Sanda; Titlić, Marina; Trkanjec, Zlatko; Demarin, Vida; Hećimović, Silva
Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia // Abstracts of trhe 8th Balkan Meeting on Human Genetics ; u: Paediatria Croatica 53 (2009) (S2)
Cavtat, Hvatska, 2009. str. 69-69 (poster, međunarodna recenzija, sažetak, znanstveni)
Malnar, M., Petek Tarnik, I., Košiček, M., Pavelin, S., Titlić, M., Trkanjec, Z., Demarin, V. & Hećimović, S. (2009) Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia. U: Abstracts of trhe 8th Balkan Meeting on Human Genetics ; u: Paediatria Croatica 53 (2009) (S2).
@article{article, author = {Malnar, Martina and Petek Tarnik, Iva and Ko\v{s}i\v{c}ek, Marko and Pavelin, Sanda and Titli\'{c}, Marina and Trkanjec, Zlatko and Demarin, Vida and He\'{c}imovi\'{c}, Silva}, year = {2009}, pages = {69-69}, keywords = {Alzheimer's disease, APP protein, Abeta peptide, biomarkers, diagnosis, neurodegeneration, tau}, title = {Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia}, keyword = {Alzheimer's disease, APP protein, Abeta peptide, biomarkers, diagnosis, neurodegeneration, tau}, publisherplace = {Cavtat, Hvatska} }
@article{article, author = {Malnar, Martina and Petek Tarnik, Iva and Ko\v{s}i\v{c}ek, Marko and Pavelin, Sanda and Titli\'{c}, Marina and Trkanjec, Zlatko and Demarin, Vida and He\'{c}imovi\'{c}, Silva}, year = {2009}, pages = {69-69}, keywords = {Alzheimer's disease, APP protein, Abeta peptide, biomarkers, diagnosis, neurodegeneration, tau}, title = {Cerebrospinal fluid biomarker analysis in Alzheimer's disease : a pilot study in Croatia}, keyword = {Alzheimer's disease, APP protein, Abeta peptide, biomarkers, diagnosis, neurodegeneration, tau}, publisherplace = {Cavtat, Hvatska} }

Časopis indeksira:


  • Scopus





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