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Pregled bibliografske jedinice broj: 397664

Mitochondrial alterations in aging rat brain: effective role of (− )-epigallo catechin gallate


Ravichandran, Srividhya; Žarković, Kamelija; Štroser, Marina; Waeg, Georg; Žarković, Neven; Kalaiselvi, Periandavan
Mitochondrial alterations in aging rat brain: effective role of (− )-epigallo catechin gallate // International journal of developmental neuroscience, 27 (2009), 3; 223-231 doi:10.1016/j.ijdevneu.2009.01.003 (međunarodna recenzija, članak, znanstveni)


Naslov
Mitochondrial alterations in aging rat brain: effective role of (− )-epigallo catechin gallate

Autori
Ravichandran, Srividhya ; Žarković, Kamelija ; Štroser, Marina ; Waeg, Georg ; Žarković, Neven ; Kalaiselvi, Periandavan

Izvornik
International journal of developmental neuroscience (0736-5748) 27 (2009), 3; 223-231

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Epigallo catechin gallate; brain; aging; mitochondria; oxidative stress

Sažetak
Aging is a multi-factorial process which involves deprivation in body's metabolism. Brain mitochondria are prone to oxidative damage owing to their high metabolic rate. The decline in antioxidant system during aging augments the neuronal damage to mitochondrial components like antioxidant system, Kreb's cycle enzymes and electron transport chain complexes. Since brain is an organ rich in fatty acids, lipid peroxidation products like hydroxynonenal are predominant. Those lipid peroxidation products conjugate with amino acids to form adducts which alter their structural and functional properties. Epigallo catechin gallate is a potent antioxidant which is rich in green tea extract. This study elucidated the antioxidant potential of epigallo catechin gallate to counteract the mitochondrial oxidative damage in brain. The study comprised of young (3– 4 months old ; 150 ± 20 g) and aged (above 24 months ; 420 ± 20 g) male albino rats of Wistar strain in Groups I and II. Groups III and IV comprised of young and aged rats supplemented with epigallo catechin gallate (2 mg/kg body weight) for 30 days. Antioxidants, Kreb's cycle enzymes and electron transport chain complexes were assayed in the mitochondrial fraction. Hydroxynonenal expression was carried out using immunohistochemical analysis. Epigallo catechin gallate supplementation decreased the expression of hydroxynonenal in aged brain, up-regulated the antioxidant system and augmented the activities of Kreb's cycle enzymes and electron transport chain complexes in aged brain mitochondria thus proving its antioxidant potential at the level of mitochondria.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)
  • PsychINFO
  • PsycLit (Psychological Abstracts)


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