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Pregled bibliografske jedinice broj: 397168

Antioxidant activity of NSAID hydroxamic acids


Zovko Končić, Marijana; Rajić, Zrinka; Petrić, Neva; Zorc, Branka
Antioxidant activity of NSAID hydroxamic acids // Acta pharmaceutica, 59 (2009), 2; 235-242 doi:10.2478/v10007-009-0017-8 (međunarodna recenzija, kratko priopcenje, znanstveni)


CROSBI ID: 397168 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Antioxidant activity of NSAID hydroxamic acids

Autori
Zovko Končić, Marijana ; Rajić, Zrinka ; Petrić, Neva ; Zorc, Branka

Izvornik
Acta pharmaceutica (1330-0075) 59 (2009), 2; 235-242

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
NSAID; hydroxamic acid; antioxidant activity; radical scavenging activity; metal chelating activity

Sažetak
In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0 % and EC50 = 60.1 mg mL– 1). The activity of the standard substance, butylated hydroxyanisole, in the two assays was ANT = 86.9 % and EC50 = 18.8 mg mL– 1, respectively. Ibuproxam was the strongest iron chelator among investigated hydroxamic acids (EC50 = 255.6 mg mL– 1), yet significantly weaker than the standard substance, EDTA (EC50 = 29.1 mg mL– 1). It seems that different mechanism is involved in metal chelating activity than in antioxidant and radical scavenging activity. Antioxidant and radical scavenging activities may be connected with conjugation of the nitrogen lone electron pair with the carbonyl group. On the other hand, more hydrophilic substances tend to be better iron chelators.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
3917 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, MZOS)
3932 - Antioksidativni i prooksidativni učinak ljekovitih biljnih vrsta na hepatocite (Roberta Petlevski, MZOS)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Branka Zorc (autor)

Avatar Url Marijana Zovko Končić (autor)

Citiraj ovu publikaciju

Zovko Končić, Marijana; Rajić, Zrinka; Petrić, Neva; Zorc, Branka
Antioxidant activity of NSAID hydroxamic acids // Acta pharmaceutica, 59 (2009), 2; 235-242 doi:10.2478/v10007-009-0017-8 (međunarodna recenzija, kratko priopcenje, znanstveni)
Zovko Končić, M., Rajić, Z., Petrić, N. & Zorc, B. (2009) Antioxidant activity of NSAID hydroxamic acids. Acta pharmaceutica, 59 (2), 235-242 doi:10.2478/v10007-009-0017-8.
@article{article, year = {2009}, pages = {235-242}, DOI = {10.2478/v10007-009-0017-8}, keywords = {NSAID, hydroxamic acid, antioxidant activity, radical scavenging activity, metal chelating activity}, journal = {Acta pharmaceutica}, doi = {10.2478/v10007-009-0017-8}, volume = {59}, number = {2}, issn = {1330-0075}, title = {Antioxidant activity of NSAID hydroxamic acids}, keyword = {NSAID, hydroxamic acid, antioxidant activity, radical scavenging activity, metal chelating activity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • International Pharmaceutical Abstracts (IPA)


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