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Novel Mannosyl Derivatives of Peptidoglycan monomer : Synthesis and Biological Evaluation of Immunomodulatory Properties


Ribić, Rosana; Habjanec, Lidija; Brgles, Marija; Tomić, Srđanka; Tomašić, Jelka
Novel Mannosyl Derivatives of Peptidoglycan monomer : Synthesis and Biological Evaluation of Immunomodulatory Properties // Bioorganic & medicinal chemistry, 17 (2009), 6096-6105 doi::10.1016/j.bmc.2009.06.016 (međunarodna recenzija, članak, znanstveni)


Naslov
Novel Mannosyl Derivatives of Peptidoglycan monomer : Synthesis and Biological Evaluation of Immunomodulatory Properties

Autori
Ribić, Rosana ; Habjanec, Lidija ; Brgles, Marija ; Tomić, Srđanka ; Tomašić, Jelka

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 17 (2009); 6096-6105

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Peptidoglycan monomer; mannosides; immunostimulating activity; N-acetylmuramyl-L-alanine amidase

Sažetak
The aim of this work was to prepare mannosyl derivatives of peptidoglycan monomer (PGM, β -D-GlcNAc-(1→ 4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(ε NH2)-D-Ala-D-Ala) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Novel Man-OCH2CH(CH3)CO-PGM isomers were substrates for N-acetylmuramyl-L-alanine amidase, like the parent PGM molecule. Adjuvant activity of Man-OCH2CH(CH3)CO-PGM was tested in the mouse model using ovalbumin as an antigen.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
021-0212432-2431 - Nove formulacije antigena i imunostimulatora - utjecaj na imunoreakciju (Ruža Frkanec, )
119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Srđanka Tomić-Pisarović, )

Ustanove
Imunološki zavod d.d.,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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