Novel Mannosyl Derivatives of Peptidoglycan monomer : Synthesis and Biological Evaluation of Immunomodulatory Properties (CROSBI ID 150524)
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Podaci o odgovornosti
Ribić, Rosana ; Habjanec, Lidija ; Brgles, Marija ; Tomić, Srđanka ; Tomašić, Jelka
engleski
Novel Mannosyl Derivatives of Peptidoglycan monomer : Synthesis and Biological Evaluation of Immunomodulatory Properties
The aim of this work was to prepare mannosyl derivatives of peptidoglycan monomer (PGM, β -D-GlcNAc-(1→ 4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(ε NH2)-D-Ala-D-Ala) in order to study the effects of mannosylation on adjuvant (immunostimulating) activity. Novel Man-OCH2CH(CH3)CO-PGM isomers were substrates for N-acetylmuramyl-L-alanine amidase, like the parent PGM molecule. Adjuvant activity of Man-OCH2CH(CH3)CO-PGM was tested in the mouse model using ovalbumin as an antigen.
peptidoglycan monomer; mannosides; immunostimulating activity; N-acetylmuramyl-L-alanine amidase
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Podaci o izdanju
Povezanost rada
Kemija, Temeljne medicinske znanosti