engleski

P-300 in Evaluation of Cognitive Impairment of Long-term exposure to Xylene

Chronic-low level exposure to xylene may be featured by impaired memory. We tried to determine the effects of chronic exposure of low concentrations of xylene on cognitive ability. A group of 35 medical workers, 36+7.7 yrs, from a pathology department occupationally exposed to xylene through inhalation for at least five years was studied by auditory event-related potentials. The results were compared with those obtained from the control group of 21 subjects, 40+9.4. The exposure to xylene was confirmed through determination of m-methylhippuric acid, a reliable biological indicator of xylene exposure, in pre- and post-shift urine. The group of medical workers showed significantly longer P300 log latency (p=0.263). Cognitive impairment may occur in workers chronically exposed to low levels of xylene.

kognitivna neurofiziologija; ksilen

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