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Pregled bibliografske jedinice broj: 395760

Differential susceptibility of RAE-1 isoforms to murine cytomegalovirus


Arapović, Jurica; Lenac, Tihana; Antulov, Ronald; Polić, Bojan; Carayannopoulos, L.N.; Krmpotić, Astrid; Jonjić, Stipan
Differential susceptibility of RAE-1 isoforms to murine cytomegalovirus // NK2008 11th Meeting of the Society for Natural Immunity, Fremantle, Western Australia, 26th - 30th October 2008 / Adoniou C. , Coudert (ur.).
Fremantle, 2008. str. 40-40 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Differential susceptibility of RAE-1 isoforms to murine cytomegalovirus

Autori
Arapović, Jurica ; Lenac, Tihana ; Antulov, Ronald ; Polić, Bojan ; Carayannopoulos, L.N. ; Krmpotić, Astrid ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
NK2008 11th Meeting of the Society for Natural Immunity, Fremantle, Western Australia, 26th - 30th October 2008 / Adoniou C. , Coudert - Fremantle, 2008, 40-40

Skup
NK2008 11th Meeting of the Society for Natural Immunity, Fremantle, Western Australia, 26th - 30th October 2008

Mjesto i datum
Fremantle, Australia, 26.-30.10.2008.

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; NKG2D; RAE-1; immunoevasion

Sažetak
NKG2D receptor is one of the most potent activating NK cell receptors involved in antiviral responses. NKG2D ligands in mouse are MULT-1, H60 and RAE-1 family of proteins. We and others have characterized several murine cytomegalovirus (MCMV) proteins involved in the down-modulation of NKG2D ligands. Among these, the gp40 encoded by m152 gene, originally described for its ability to block the maturation of MHC I molecules was also involved in down-modulation of RAE-1 proteins. Based on our initial observations suggesting that in some mouse strains the NKG2D-dependent control is preserved even in response to wild type MCMV, we postulated that there must be NKG2D ligands that resist the virus mediated down-modulation. Here we show that the RAE-1 proteins differ in their susceptibility to the down-regulation by MCMV due to intrinsic differences in stability of the mature surface-expressed protein. In contrast to RAE-1gamma, representing the sensitive isoform, RAE-1delta remains present on the surface of MCMV-infected cells. However, although unable to affect the mature RAE-1delta form, m152 retains the newly synthesized RAE-1delta as well as RAE-1gamma in the endoplasmic reticulum. The different stabilities of RAE-1 isoforms during MCMV infection can be attributed to the absence of the PLWY motif from RAE-1delta.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Stipan Jonjić, )
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Astrid Krmpotić, )
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Bojan Polić, )

Ustanove
Medicinski fakultet, Rijeka