engleski

Polycythemia as the first manifestation of Cushing's disease

70-yr-old women was referred to our department because of osteoporosis. She was previously followed by a hematologist for 1 year because of unexplained erythrocytosis with normal platelt and leukocyte count. Endocrinological evaluation showed preserved circadian rhythm of cortisol secretion, and the reverse rhythm of ACTH, with slightly elevated 24-h urinary free cortisol level. The overnight dexamethason suppression test showed inadequate cortisol suppression. MR disclosed a pituitary tumor. Transsphenoid tumor ablation was carried out. Pathohistology and immunohystochemistry revealed corticotropinoma. Six month after operation patient had erythrocytes count within normal limits.

polycythemia ; Cushing's disease

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