Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 39561

Diazenes: modificators of tumor cell resistance to cisplatin


Osmak, Maja; Bordukalo, Tatjana; Košmrlj, Janez; Kvajo, Mirna; Marijanović, Zrinka; Eljuga, Damir; Polanc, Slovenko
Diazenes: modificators of tumor cell resistance to cisplatin // Neoplasma, 46 (1999), 4; 201-206 (međunarodna recenzija, članak, znanstveni)


Naslov
Diazenes: modificators of tumor cell resistance to cisplatin

Autori
Osmak, Maja ; Bordukalo, Tatjana ; Košmrlj, Janez ; Kvajo, Mirna ; Marijanović, Zrinka ; Eljuga, Damir ; Polanc, Slovenko

Izvornik
Neoplasma (0028-2685) 46 (1999), 4; 201-206

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
drug resistance; diazenes; tumor cells; glutathione; cisplatin

Sažetak
Most studies indicate that modulation of glutathione metabolism may be one of the most promissing means of reversing clinical drug resistance. Five new diazene compounds have been synthesized: JK-279, JK-835, JK-913, JK-925 and LV-57 that should, according to their structure and biochemical properties, lower the GSH concentration. In the present study, we examined the influence of diazenes on cisplatin resistance in human cervical (HeLa) and laryngeal carcinoma (HEp2) cells as well as in their cisplatin-resistant sublines (HeLaCA and CK2, respectively). Intracellular GSH content was examined spectrophotometrically by the procedure developed by Tietze. The cell sensitivity to drugs was determined using a modified colorimetric MTT assay. Results show that all examined diazenes lowered GSH concentration. This decrease was insignificant for JK-835 and JK-925 in HeLa and HeLaCA cells, and JK-925 in CK2 cells. In human cervical carcinoma HeLa and HeLaCA cells, JK-279 was mostly active in sensitizing the cells to cisplatin, especially in drug-resistant cells. JK-913, JK-835 and LV-57 reverted partially resistace to cisplatin in HEp2 cells, while none of the diazenes was active in CK2 cells. In conclusion, diazene JK-279 may be useful in the combined treatment (cisplatin + diazene) for the certain type of cancer.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
00981008

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Osmak (autor)

Avatar Url Damir Eljuga (autor)

Avatar Url Tatjana Bordukalo Nikšić (autor)

Citiraj ovu publikaciju

Osmak, Maja; Bordukalo, Tatjana; Košmrlj, Janez; Kvajo, Mirna; Marijanović, Zrinka; Eljuga, Damir; Polanc, Slovenko
Diazenes: modificators of tumor cell resistance to cisplatin // Neoplasma, 46 (1999), 4; 201-206 (međunarodna recenzija, članak, znanstveni)
Osmak, M., Bordukalo, T., Košmrlj, J., Kvajo, M., Marijanović, Z., Eljuga, D. & Polanc, S. (1999) Diazenes: modificators of tumor cell resistance to cisplatin. Neoplasma, 46 (4), 201-206.
@article{article, year = {1999}, pages = {201-206}, keywords = {drug resistance, diazenes, tumor cells, glutathione, cisplatin}, journal = {Neoplasma}, volume = {46}, number = {4}, issn = {0028-2685}, title = {Diazenes: modificators of tumor cell resistance to cisplatin}, keyword = {drug resistance, diazenes, tumor cells, glutathione, cisplatin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus
  • Index Medicus