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Pregled bibliografske jedinice broj: 395529

Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA


Rusak, Gordana; Piantanida, Ivo; Bretschneider, Sabine, Ludwig-Müller, Jutta
Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA // Journal of Inorganic Biochemistry, 103 (2009), 12; 1597-1601 doi:10.1016/j.jinorgbio.2009.08.008 (međunarodna recenzija, članak, znanstveni)


Naslov
Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA

Autori
Rusak, Gordana ; Piantanida, Ivo ; Bretschneider, Sabine, Ludwig-Müller, Jutta

Izvornik
Journal of Inorganic Biochemistry (0162-0134) 103 (2009), 12; 1597-1601

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Flavonoids; Rare Earth Metals; Cucumber Mosaic Virus; Nucleic Acids

Sažetak
Due to broad spectrum of biological activities of flavonoids, their target molecules in the cell are intensively studied. We examined the interactions of flavonoid quercetin (Q) and its lanthanum complex (QLa3+) with plant viral satellite (sat) dsRNA. Comparison of the cumulative binding and the estimated intercalative binding constant pointed towards an additional binding mode of quercetin to exclusively viral dsRNA, which is not recorded for synthetic dsRNAs. The QLa3+ showed significantly higher affinity toward viral dsRNA than Q and La3+ alone, most likely as the consequence of quercetin intercalation accompanied by additional electrostatic interaction of La3+ with the negatively charged viral RNA backbone.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )
119-1191192-1213 - Flavonoidi i molekularni mehanizmi njihovih bioloških učinaka (Gordana Rusak, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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