Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA (CROSBI ID 150289)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Rusak, Gordana ; Piantanida, Ivo ; Bretschneider, Sabine, Ludwig-Müller, Jutta
engleski
Complex formation of quercetin with lanthanum enhances binding to plant viral satellite double stranded RNA
Due to broad spectrum of biological activities of flavonoids, their target molecules in the cell are intensively studied. We examined the interactions of flavonoid quercetin (Q) and its lanthanum complex (QLa3+) with plant viral satellite (sat) dsRNA. Comparison of the cumulative binding and the estimated intercalative binding constant pointed towards an additional binding mode of quercetin to exclusively viral dsRNA, which is not recorded for synthetic dsRNAs. The QLa3+ showed significantly higher affinity toward viral dsRNA than Q and La3+ alone, most likely as the consequence of quercetin intercalation accompanied by additional electrostatic interaction of La3+ with the negatively charged viral RNA backbone.
Flavonoids ; Rare Earth Metals ; Cucumber Mosaic Virus ; Nucleic Acids
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Podaci o izdanju
103 (12)
2009.
1597-1601
objavljeno
0162-0134
10.1016/j.jinorgbio.2009.08.008