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Pregled bibliografske jedinice broj: 394832

Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor


Štefanić, Zoran; Vujaklija, Dušica; Luić, Marija
Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor // Acta crystallographica. Section D, Biological Crystallography, 65 (2009), 9; 974-979 doi:10.1107/S0907444909023634 (međunarodna recenzija, članak, znanstveni)


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Naslov
Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor
(Crystal structure of the single-stranded DNA binding protein from Streptomyces coelicolor)

Autori
Štefanić, Zoran ; Vujaklija, Dušica ; Luić, Marija

Izvornik
Acta crystallographica. Section D, Biological Crystallography (0907-4449) 65 (2009), 9; 974-979

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
single-stranded DNA-binding protein ; SSB ; Streptomyces coelicolor ; OB fold

Sažetak
The crystal structure of the single-stranded DNA-binding protein (SSB) from Streptomyces coelicolor, a filamentous soil bacterium with a complex life cycle and a linear chromosome, has been solved and refined at 2.1 Å resolution. The 3D-structure shows a common conserved central OB fold found in all structurally determined SSB proteins. However, it shows variations in quaternary structure found previously only in mycobacterial SSBs. The strand involved in the clamp mechanism characteristic of this type of quaternary structure leads to higher stability of the homotetramer. To the best of our knowledge this is the first X-ray structure of an SSB from a member of the genus Streptomyces and it seems to be the most stable in comparison to other structurally characterized bacterial or human mitochondrial SSBs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
098-0982913-2877 - Temeljna molekularno-biološka istraživanja streptomiceta (Dušica Vujaklija, )
098-1191344-2943 - Protein-ligand međudjelovanja na atomnoj razini (Marija Luić, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marija Luić (autor)

Avatar Url Zoran Štefanić (autor)

Avatar Url Dušica Vujaklija (autor)

Citiraj ovu publikaciju

Štefanić, Zoran; Vujaklija, Dušica; Luić, Marija
Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor // Acta crystallographica. Section D, Biological Crystallography, 65 (2009), 9; 974-979 doi:10.1107/S0907444909023634 (međunarodna recenzija, članak, znanstveni)
Štefanić, Z., Vujaklija, D. & Luić, M. (2009) Structure of the single-stranded DNA-binding protein from Streptomyces coelicolor. Acta crystallographica. Section D, Biological Crystallography, 65 (9), 974-979 doi:10.1107/S0907444909023634.
@article{article, year = {2009}, pages = {974-979}, DOI = {10.1107/S0907444909023634}, keywords = {single-stranded DNA-binding protein, SSB, Streptomyces coelicolor, OB fold}, journal = {Acta crystallographica. Section D, Biological Crystallography}, doi = {10.1107/S0907444909023634}, volume = {65}, number = {9}, issn = {0907-4449}, title = {Crystal structure of the single-stranded DNA binding protein from Streptomyces coelicolor}, keyword = {single-stranded DNA-binding protein, SSB, Streptomyces coelicolor, OB fold} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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