engleski

Highly Expressed Genes In Marine Sponge Suberites domuncula Prefer C- and G- Ending Codons

Sponges are the simplest extant phylum of Metazoa ; they are closest to the common ancestor of all multicellular animals. A total of 223 coding sequences from Suberites domuncula (Demospongiae) represent the dataset for the codon usage analysis. A total of 46038 codons had an average G + C content of 45.8 % and average GC3S (G + C content at silent codon position) was 43.4 %. In this sample of genes considerable variations in synonymous codon usage were found. The G + C content of coding sequences varied from 34 to 56.1 % and GC3S from 19 to 58.7 %. Correspondence analysis revealed that highly expressed genes preferentially use a limited subset of codons (preferred codons). A total of 15 preferred codons were found and they all, with one exception, end with C or G. We propose that the preferential use of C- and G-ending codons in highly expressed genes was already developed in a common ancestor of sponges and other Metazoa and it remained conserved throughout sponge evolution.

Porifera ; Suberites domuncula ; codon usage

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