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The shape of the aortic outflow velocity profile revisited. Is there a relation to contractile function in coronary artery disease? An automated analysis using mathematical modeling (CROSBI ID 547827)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Čikeš, Maja ; Kalinić, Hrvoje ; Baltabaeva, Aigul ; Lončarić, Sven ; Parsai, Chirine ; Miličić, Davor ; Čikeš, Ivo ; Sutherland, George R. ; Bijnens, Bart The shape of the aortic outflow velocity profile revisited. Is there a relation to contractile function in coronary artery disease? An automated analysis using mathematical modeling // Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora / Miličić, Davor ; Čikeš, Maja (ur.). 2008. str. 60-60

Podaci o odgovornosti

Čikeš, Maja ; Kalinić, Hrvoje ; Baltabaeva, Aigul ; Lončarić, Sven ; Parsai, Chirine ; Miličić, Davor ; Čikeš, Ivo ; Sutherland, George R. ; Bijnens, Bart

engleski

The shape of the aortic outflow velocity profile revisited. Is there a relation to contractile function in coronary artery disease? An automated analysis using mathematical modeling

Myocardium contracts in the beginning of ejection causing outflow acceleration, resulting in asymmetric velocity profiles peaking around 1/3 of ejection and declining when force development declines. We hypothesized that decreased contractility in coronary artery disease (CAD) might change outflow timing and shape. 79 patients undergoing routine full dose dobutamine stress-echo (DSE) were divided into 2 groups based on resting wall-motion and DSE-response: CAD negative (CADneg) (35/79) and positive (CADpos) (44/79) which were compared to 32 healthy volunteers. Aortic CW-Doppler traces at rest were analyzed semi-automatically ; time-to-peak (Tmod), ejection-time (ETmod), rise- (trise) and fall-time (tfall) were quantified. Asymmetry (asymm) was calculated as the normalized difference of left and right half of the spectrum. Normal curves were triangular, early-peaking, while patients showed more rounded shapes and later peaks. Tmod was significantly increased in CADpos. Tmod/ETmod was significantly longer in CADpos, compared to controls and shortest in CADneg. Trise was longest in CADpos. Tfall was shortest in CADpos, followed by controls and CADneg. Asymm was lowest in CADpos, followed by controls and CADneg. Abnormally symmetric profiles (asymm<0.25) were found in none of the controls, 2.9% CADneg and 27.3% CADpos. A good correlation was found between assym and ejection fraction (EF) and Tmod/ETmod and EF. Notably, an LV dynamic gradient was induced in 71.4% CADneg and in 18.2% CADpos, associated with LV hypertrophy and supernormal (very asymmetric) traces. Decreased contractility results in a more symmetrical outflow, while very asymmetrical traces suggest increased contractility, potentially inducing intra-cavity gradients during DSE.

left ventricular outflow; doppler echocardiography; coronary artery disease

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Podaci o prilogu

60-60.

2008.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora

Miličić, Davor ; Čikeš, Maja

Zagreb: Hrvatski liječnički zbor

0024-3477

Podaci o skupu

Congress of the Croatian Cardiac Society with International Participation (7 ; 2008)

predavanje

16.10.2008-19.10.2008

Opatija, Hrvatska

Povezanost rada

Računarstvo, Kliničke medicinske znanosti, Informacijske i komunikacijske znanosti

Indeksiranost