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The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats (CROSBI ID 149990)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lazarus, Maja ; Orct, Tatjana ; Jurasović, Jasna ; Blanuša, Maja The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats // BioMetals, 22 (2009), 6; 973-983. doi: 10.1007/s10534-009-9249-9

Podaci o odgovornosti

Lazarus, Maja ; Orct, Tatjana ; Jurasović, Jasna ; Blanuša, Maja

engleski

The effect of dietary selenium supplementation on cadmium absorption and retention in suckling rats

Selenium (Se) reduces cadmium (Cd) toxicity in adult animals, but its effects in newborn animals are still unknown. This study investigated Cd (as CdCl2) absorption, distribution, and retention in suckling rats receiving oral Se supplementation (as Na2SeO3) in equimolar doses (8 μ mol Cd and/or Se per kg b.w./day). Selenium was given either before and during Cd exposure (Sepre+Cd group ; pre-treatment group) or only during Cd exposure (Se+Cd group). Rats were treated from postnatal day (PND) 6 to 14 as follows: controls (H2O, PND 6-14), Se (PND 10-14), Cd (PND 10-14), Sepre+Cd (Se PND 6-14 + Cd PND 10-14) and Se+Cd (Se + Cd PND 10-14). Selenium supplementation, especially pre-treatment, decreased Cd levels in the blood, brain, liver and kidney of suckling rats and Cd excretion. Selenium levels in plasma, brain, and kidney also decreased. These findings suggest that higher Se intake could efficiently reduce Cd retention during the suckling period.

cadmium; interaction; selenium; suckling rat; trace elements

Published online: 5 June 2009 (Springer Link)

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Podaci o izdanju

22 (6)

2009.

973-983

objavljeno

0966-0844

10.1007/s10534-009-9249-9

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

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