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Pregled bibliografske jedinice broj: 393254

Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study


Huić, Dražen; Mutvar, Andrea; Kinda-Bašić, Sandra; Aurer, Igor; Ciglar, Martina; Grošev, Darko; Radman, Ivo; Labar, Boris; Dodig, Damir
Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study // Radiology and oncology, 43 (2009), 4; 258-263 doi:10.2478/v10019-0024-x (međunarodna recenzija, članak, znanstveni)


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Naslov
Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study

Autori
Huić, Dražen ; Mutvar, Andrea ; Kinda-Bašić, Sandra ; Aurer, Igor ; Ciglar, Martina ; Grošev, Darko ; Radman, Ivo ; Labar, Boris ; Dodig, Damir

Izvornik
Radiology and oncology (1318-2099) 43 (2009), 4; 258-263

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Hodgkin’ s disease; fluorine-18-fluorodeoxyglucose; FDG; PET; coincidence; therapy monitoring; prognosis; follow-up; negative predictive value

Sažetak
Aim: To asses the negative predictive value (NPV) of FDG-PET performed with triple-head coincidence gamma camera after first-line therapy or salvage therapy in patients with Hodgkin’ s disease (HD) compared by long-term follow-up as a reference standard. Design and Setting: This retrospective diagnostic test study was done in University Hospital Centre Zagreb between June 2001 and February 2008. Participants: The charts of 131 consecutive patients with Hodgkin’ s disease were reviewed. Seventy-three consecutive PET-negative patients (median age 28 years ; range 12-80 years) with primary or recurrent biopsy confirmed lymphoma after first-line therapy or salvage therapy were followed-up at least 12 months (median 23 months ; range 12-69 months). All already performed 18F-FDG PET scans (using hybrid PET camera with triple head coincidence imaging capability within a few months after completion of therapy) were again visually interpreted by two board-certified nuclear medicine physicians who were blinded to any clinical or CT data. Main outcome measure: The negative predictive value of FDG-PET performed with triple-head coincidence gamma camera (Index test) was compared with long-term follow-up as a reference standard. Results: Out of 131 patients 73 turned-out to be PET-negative. Of those 73 PET-negative patients, 61 have been scanned after first-line chemotherapy/radiotherapy, and only 3 of them relapsed in a follow-up (negative predictive value 0.95). Twelve patients with resistant disease have been scanned after repeated therapy, and 4 of them relapsed in a follow-up period (negative predictive value 0.66). Conclusions: This methodology with triple-head coincidence gamma camera has high negative predictive value. A negative PET scan can reassure patients and their doctors that disease is not active.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0362214-0127 - Korekcija gušenje zračenja u emisijskoj tomografiji srca (Dodig, Damir, MZOS ) ( POIROT)
108-1081872-1908 - Dijagnostika i liječenje limfoma (Aurer, Igor, MZOS ) ( POIROT)
108-1081872-2062 - Uloga pozitronske emisijske tomografije (PET) u bolesnika sa zloćudnim tumorima (Huić, Dražen, MZOS ) ( POIROT)
214-0362214-2055 - Kvantifikacija i parametrizacija akumulacije FDG-a pomoću PET-a (Lončarić, Srećko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Boris Labar (autor)

Avatar Url Damir Dodig (autor)

Avatar Url Igor Aurer (autor)

Avatar Url Ivo Radman-Livaja (autor)

Avatar Url Darko Grošev (autor)

Citiraj ovu publikaciju

Huić, Dražen; Mutvar, Andrea; Kinda-Bašić, Sandra; Aurer, Igor; Ciglar, Martina; Grošev, Darko; Radman, Ivo; Labar, Boris; Dodig, Damir
Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study // Radiology and oncology, 43 (2009), 4; 258-263 doi:10.2478/v10019-0024-x (međunarodna recenzija, članak, znanstveni)
Huić, D., Mutvar, A., Kinda-Bašić, S., Aurer, I., Ciglar, M., Grošev, D., Radman, I., Labar, B. & Dodig, D. (2009) Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study. Radiology and oncology, 43 (4), 258-263 doi:10.2478/v10019-0024-x.
@article{article, year = {2009}, pages = {258-263}, DOI = {10.2478/v10019-0024-x}, keywords = {Hodgkin’ s disease, fluorine-18-fluorodeoxyglucose, FDG, PET, coincidence, therapy monitoring, prognosis, follow-up, negative predictive value}, journal = {Radiology and oncology}, doi = {10.2478/v10019-0024-x}, volume = {43}, number = {4}, issn = {1318-2099}, title = {Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study}, keyword = {Hodgkin’ s disease, fluorine-18-fluorodeoxyglucose, FDG, PET, coincidence, therapy monitoring, prognosis, follow-up, negative predictive value} }
@article{article, year = {2009}, pages = {258-263}, DOI = {10.2478/v10019-0024-x}, keywords = {Hodgkin’ s disease, fluorine-18-fluorodeoxyglucose, FDG, PET, coincidence, therapy monitoring, prognosis, follow-up, negative predictive value}, journal = {Radiology and oncology}, doi = {10.2478/v10019-0024-x}, volume = {43}, number = {4}, issn = {1318-2099}, title = {Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin's disease and a residual mass after therapy: a retrospective diagnostic test study}, keyword = {Hodgkin’ s disease, fluorine-18-fluorodeoxyglucose, FDG, PET, coincidence, therapy monitoring, prognosis, follow-up, negative predictive value} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)
  • Chemical Abstracts Service
  • Journal Citation Report
  • Open J-gate
  • Scopus


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