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Pregled bibliografske jedinice broj: 393174

Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats


Ilić, Spomenko; Drmić, Domagoj; Žarković, Kamelija; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Djuzel, Viktor et al.
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats // European journal of pharmacology, 667 (2011), 1-3; 322-329 doi:10.1016/j.ejphar.2011.05.038 (međunarodna recenzija, članak, znanstveni)


Naslov
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

Autori
Ilić, Spomenko ; Drmić, Domagoj ; Žarković, Kamelija ; Kolenc, Danijela ; Ćorić, Marijana ; Brčić, Luka ; Kliček, Robert ; Radić, Božo ; Sever, Marko ; Djuzel, Viktor ; Ivica, Mihovil ; Boban Blagaić, Alenka ; Zoričić, Zoran ; Anić, Tomislav ; Zoričić, Ivan ; Džidić, Senka ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
European journal of pharmacology (0014-2999) 667 (2011), 1-3; 322-329

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Paracetamol ; hepatic encephalopathy ; convulsions ; pentadecapeptide BPC 157 ; rats

Sažetak
We challenged rats with chronic ibuprofen application (0.4g/kg intraperitoneally once daily for 4 weeks) and the stable gastric pentadecapeptide BPC 157 therapy. We evidenced a deleterious circuit not reported in ibuprofen-rats as yet: hepatic encephalopathy, gastric lesions, hepatomegaly, increased AST and ALT serum values, with prolonged sedation/unconsciousness and weight loss. In particular, ibuprofen toxicity exhibited itself as brain edema and cyanosis, particularly in the cerebellum, more so in white than in gray mater, damaged (balonized) red neurons, without any inflammatory reaction, particularly in the cerebral cortex and cerebellar nuclei, less in the hippocampus, dentate nucleus and Purkinje cells. BPC 157 (GEPPPGKPADDAGLV, MW 1419, 10µ ; g, 10ng/kg) was fully effective given as an antidote after ibuprofen: (i) intraperitoneally, immediately after ibuprofen or (ii) in drinking water (0.16 µ ; g, 0.16 ng/ml) until the end of the 4 week-experiment. Thus, apart from its role as an anti-ulcer peptide, efficient in inflammatory bowel disease trials (PL14736) and various wound treatment, with no toxicity reported and which already showed various hepatoprotective effects, either BPC 157 regimen counteracted

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
108-0532264-0048 - Hepatocelularni tumori (Marijana Ćorić, )
108-1080321-0389 - Utjecaj pentadekapeptida BPC 157 na ženski urogenitalni sustav (Hrvoje Vrčić, )
108-1083570-3634 - Genetička istraživanja učinka BPC-157 na mikroorganizmima (Senka Džidić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3636 - Učinak BPC 157 na induciranu bilijarnu opstrukciju (Tomislav Anić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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