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Pregled bibliografske jedinice broj: 393154

High hepatotoxic dose of paracetamol produces generalised convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)


Ilić, Spomenko; Drmić, Domagoj; Žarković, Kamelija; Kolenc, Danijela; Ćorić, Marijana; Brčić, Luka; Kliček, Robert; Radić, Božo; Sever, Marko; Djuzel, Viktor et al.
High hepatotoxic dose of paracetamol produces generalised convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736) // Journal of physiology and pharmacology, 61 (2010), 2; 241-250 (međunarodna recenzija, članak, znanstveni)


Naslov
High hepatotoxic dose of paracetamol produces generalised convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736)

Autori
Ilić, Spomenko ; Drmić, Domagoj ; Žarković, Kamelija ; Kolenc, Danijela ; Ćorić, Marijana ; Brčić, Luka ; Kliček, Robert ; Radić, Božo ; Sever, Marko ; Djuzel, Viktor ; Ivica, Mihovil ; Boban Blagaić, Alenka ; Zoričić, Zoran ; Anić, Tomislav ; Zoričić, Ivan ; Džidić, Senka ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Journal of physiology and pharmacology (0867-5910) 61 (2010), 2; 241-250

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Paracetamol- hepatic encephalopathy ; convulsions -pentadecapeptide BPC 157 ; rats

Sažetak
To date, paracetamol hepatic encephalopathy with generalized convulsions was not reported in rats. After a single paracetamol overdose (5g/kg intraperitoneally), an acute hepatic toxicity and a progressive encephalopathy with severe seizures and a very early onset, appeared in rats. These were all counteracted by the stable gastric pentadecapeptide BPC 157 (GEPPPGKPADDAGLV, MW 1419, an anti-ulcer peptide efficient in inflammatory bowel disease trials (PL 14736), no toxicity reported), which showed hepatoprotective effects. After paracetamol, BPC 157 was applied (10µ ; ; g, 10ng/kg, intraperitoneally or intragastrically) (i)prophylactically, immediately after or (ii)therapeutically, after 3 hours elapsed. At 25 min post-paracetamol only ALT and AST serum values increased for the liver lesion, but in several brain areas, significant damage became apparent, accompanied by generalized convulsions. Through the next 5 hour seizure period and thereafter, the brain damage, liver damage and enzyme values increased, particularly throughout the 3h-24h post-paracetamol period. BPC 157 demonstrated clinical (no convulsions (prophylactic application) or convulsions rapidly disappeared (therapeutic effect within 25 min)), microscopical (markedly less liver and brain lesions) and biochemical (enzyme serum levels decreased) counteraction. Both, the prophylactic and therapeutic benefits (intraperitoneally and intragastrically) clearly imply BPC 157 as a paracetamol antidote even against highly advanced damaging processes induced by paracetamol.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2519 - Lipidi, slobodni radikali i njihovi glasnici u integrativnoj onkologiji (Neven Žarković, )
108-0000000-0028 - Oksidacijski stres i tumori središnjeg živčanog sustava (Kamelija Žarković, )
108-0532264-0048 - Hepatocelularni tumori (Marijana Ćorić, )
108-1080321-0389 - Utjecaj pentadekapeptida BPC 157 na ženski urogenitalni sustav (Hrvoje Vrčić, )
108-1083570-3634 - Genetička istraživanja učinka BPC-157 na mikroorganizmima (Senka Džidić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3636 - Učinak BPC 157 na induciranu bilijarnu opstrukciju (Tomislav Anić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE