Prostate-Specific Antigen (PSA) in serum in relation to blood lead concentration and alcohol consumption in men (CROSBI ID 149792)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Pizent, Alica ; Čolak, Božo ; Kljaković-Gašpić, Zorana ; Telišman, Spomenka
engleski
Prostate-Specific Antigen (PSA) in serum in relation to blood lead concentration and alcohol consumption in men
The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specific antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of influencing prostate function or metal metabolism. No significant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a significant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 μ g L-1 and (10.1 to 108.0) μ g L-1, respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The influence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.
cadmium exposure; human environmental lead exposure; lifestyle factors; prostate damage; toxic and essential metals interaction
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
60
2009.
69-78
objavljeno
0004-1254
10.2478/10004-1254-60-2009-1901
Povezanost rada
Javno zdravstvo i zdravstvena zaštita