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Prostate-Specific Antigen (PSA) in serum in relation to blood lead concentration and alcohol consumption in men


Pizent, Alica; Čolak, Božo; Kljaković-Gašpić, Zorana; Telišman, Spomenka
Prostate-Specific Antigen (PSA) in serum in relation to blood lead concentration and alcohol consumption in men // Arhiv za higijenu rada i toksikologiju, 60 (2009), 69-78 doi:10.2478/10004-1254-60-2009-1901 (međunarodna recenzija, članak, znanstveni)


Naslov
Prostate-Specific Antigen (PSA) in serum in relation to blood lead concentration and alcohol consumption in men

Autori
Pizent, Alica ; Čolak, Božo ; Kljaković-Gašpić, Zorana ; Telišman, Spomenka

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 60 (2009); 69-78

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cadmium exposure; human environmental lead exposure; lifestyle factors; prostate damage; toxic and essential metals interaction

Sažetak
The combined influence of age, smoking, alcohol, blood lead and cadmium concentrations, and serum copper, zinc, and selenium concentrations on prostate-specific antigen (PSA) in serum was investigated in a group of 57 men aged 21 years to 40 years. The subjects had no occupational exposure to metals and no other known reasons suspected of influencing prostate function or metal metabolism. No significant correlation was found between PSA and any of the explanatory variables considered. Nevertheless, when taking into account all of the above-mentioned potentially explanatory variables, the results of stepwise multiple regression showed a significant increase in PSA with respect to an increase in blood lead, and a decrease in PSA with respect to an increase in intensity of alcohol consumption. The median and range values of blood lead concentration in the 57 men were 26.0 μ g L-1 and (10.1 to 108.0) μ g L-1, respectively. These results suggest that even a low-level environmental lead exposure, common for general populations worldwide, may contribute to the risk of prostate cancer in men. The influence of lead as well as cadmium, zinc, and selenium on prostate damage and PSA should be further investigated in relatively young men for the purpose of disease prevention.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
022-0222411-2408 - Učinci toksičnih i esencijalnih metala na reprodukcijsko zdravlje muškaraca (Alica Pizent, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Biological Sciences
  • BIOSIS Previews (Biological Abstracts)
  • MEDLINE
  • Pollution Abstracts
  • Water Resources Abstracts
  • SCI Expanded
  • Scopus
  • Animal Science Database
  • Greenfile
  • INIS
  • Veterinary Science Database


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