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Ratio of exercise and recovery systolic blood pressure integrals in prediction of coronary artery disease

This study was performed to determine whether the ratio (Q = A/B) of area A under the curve of exercise systolic blood pressure (SBP) increase and area B under curve of recovery SBP decrease is predictive of angiographic coronary artery disease (CAD). Patients who performed exercise testing and subsequently underwent coronary angiography, within three months, were analyzed in this study. According to angiographic report, patients were divided in three groups: without disease or with stenosis less than 50% (group 1), significant (group 2), and severe (group 3). Severe disease was defined as left main, three-vessel or two-vessel disease with involvement of proximal left anterior descending artery. There were 137 patients included in this study (age 59 &#177; 10, 70% male). Group 1 included 57%, group 2 included 30%, and group 3 included 13% of patients. Mean values of the Q ratio were 2.72 &#177; 0.9, 1.74 &#177; 0.76, 1.01 &#177; 0.38 in groups 1, 2 and 3, respectively. By means of robust discrimination analysis, statistically significant difference between groups 1, 2 and 3 in values of the ratio Q (p < 0.001) was found. The ratio of exercise SBP increase and recovery SBP decrease areas under the curve suggests severity of CAD.

systolic pressure; area under curve; exercise test; coronary angiography; coronary artery disease

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