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The phytohormone auxin induces G1 cell cycle arrest of human tumor cells


Ester, Katja; Ćurković-Perica, Mirna; Kralj Marijeta
The phytohormone auxin induces G1 cell cycle arrest of human tumor cells // Planta medica, 75 (2009), 13; 1423-1426 doi:10.1055/s-0029-1185805 (međunarodna recenzija, pismo, znanstveni)


Naslov
The phytohormone auxin induces G1 cell cycle arrest of human tumor cells

Autori
Ester, Katja ; Ćurković-Perica, Mirna ; Kralj Marijeta

Izvornik
Planta medica (0032-0943) 75 (2009), 13; 1423-1426

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo, znanstveni

Ključne riječi
IAA ; IBA ; NAA ; 2 ; 4-D ; human tumor cells ; G1 arrest

Sažetak
The plant hormone auxin is the key regulator of plant growth and development. Auxin regulates transcription of plant genes by targeting transcriptional repressor Aux/IAA to degradation. While there are many reports describing its potential to modulate human cell functions, the majority is based on auxin action following enzymatic activation. A study focused on auxin alone and its antiproliferative potential, with the emphasis on the modulation of the cell cycle, has not been performed. Therefore, we analyzed tumor growth inhibitory effect and the cell cycle perturbations of natural (IAA, IBA) and synthetic (NAA, 2, 4-D) auxins. All derivatives showed cytostatic effect on selected human tumor cell lines. The cell cycle analysis revealed that IAA and 2, 4-D induce strong G1 arrest, along with drastic decrease of S phase-cells percentage in MCF-7 cell line. This phenomenon points that auxins may have a novel unexploited antitumor potential and should be further investigated.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
119-1191192-1215 - Biološka kontrola biljnih bolesti (Mirna Ćurković-Perica, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Citiraj ovu publikaciju

Ester, Katja; Ćurković-Perica, Mirna; Kralj Marijeta
The phytohormone auxin induces G1 cell cycle arrest of human tumor cells // Planta medica, 75 (2009), 13; 1423-1426 doi:10.1055/s-0029-1185805 (međunarodna recenzija, pismo, znanstveni)
Ester, K., Ćurković-Perica, M. & Kralj Marijeta (2009) The phytohormone auxin induces G1 cell cycle arrest of human tumor cells. Planta medica, 75 (13), 1423-1426 doi:10.1055/s-0029-1185805.
@article{article, year = {2009}, pages = {1423-1426}, DOI = {10.1055/s-0029-1185805}, keywords = {IAA, IBA, NAA, 2, 4-D, human tumor cells, G1 arrest}, journal = {Planta medica}, doi = {10.1055/s-0029-1185805}, volume = {75}, number = {13}, issn = {0032-0943}, title = {The phytohormone auxin induces G1 cell cycle arrest of human tumor cells}, keyword = {IAA, IBA, NAA, 2, 4-D, human tumor cells, G1 arrest} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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