Sodium and potassium benezeneazophosphonate complexes with crown ethers (CROSBI ID 547421)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Tušek-Božić, Ljerka ; De Clercq, Erik
engleski
Sodium and potassium benezeneazophosphonate complexes with crown ethers
The synthesis and characterization of sodium and potassium benezeneazophosphonate complexes obtained by reaction in the solid state under microwave irradiation of alkali salts (Na/KA1 and Na/KA2) with crown ethers containing 18-membered (dibenzo-18-crown-6 and mtb-dibenzo-18-crown-6), 24-membered (dibenzo-24-crown-8) and 30-membered (dibenzo-30-crown-10) macrocyclic ring, was described. The simple work-up, eco-friendly solvent free reaction resulted in the formation of the mononuclear complexes in which sodium/potassium ion was bonded to oxygen atoms of the macrocycle and the phosphonic acid oxygen. The biological activity of the free crown ethers, alkali benezeneazophosphonate salts and their complexes were determined by evaluation of their antitumor activity in vitro in human T-lymphoblast CEM/0, murine leukemia L1210/0 and murine mammary carcinoma FM3A/0 cells, as well as of their antiviral activity against the human immunodeficiency viruses HIV-1 and HIV-2. The investigated compounds showed no or only marginal anti-HIV activity, whereas, all free crown ethers and their complexes demonstrated antitumor activity, which was especially high in the case of mtb-dibenzo-18-crown-6 and its complexes.
crown ether; sodium complex; potassium complex; benzeneazophosphonate
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Podaci o prilogu
212-212.
2009.
objavljeno
Podaci o matičnoj publikaciji
XXI. Hrvatski skup kemičara i kemijskih inženjera, Knjiga sažetaka (Book of Abstracts)
Pičuljan, Katarina ; Smolec, Sanja
Zagreb: Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI)
978-953-6894-38-3
Podaci o skupu
XXI. Hrvatski skup kemičara i kemijskih inženjera
poster
19.07.2009-22.07.2009
Trogir, Hrvatska