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Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats


Grabarević, Željko; Rotkvić, Ivica; Sikirić, Predrag; Seiwerth, Sven; Džaja, Petar; Perić, Josip; Kos, Josip
Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats // Acta veterinaria Hungarica, 45 (1997), 1; 85-93 (međunarodna recenzija, članak, znanstveni)


Naslov
Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats

Autori
Grabarević, Željko ; Rotkvić, Ivica ; Sikirić, Predrag ; Seiwerth, Sven ; Džaja, Petar ; Perić, Josip ; Kos, Josip

Izvornik
Acta veterinaria Hungarica 45 (1997), 1; 85-93

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Interaction; protective effect; dopaminergic system; cimetidine; dopamine agonists and antagonists; haemorrhagic gastric lesionsom
(Interaction; protective effect; dopaminergic system; cimetidine; dopamine agonists and antagonists; haemorrhagic gastric lesionso)

Sažetak
Pretreatment with dopamine agonists (bromocriptine 2.5, L-dopa 2.5, apomorphine 0.05 mg/kg i.p.) and a histamine H2 receptor antagonist (cimetidine 50.0 mg/kg i.p.) was found to greatly reduce the haomorrhagic gastric lesions induced by 15-min pylorus ligation in rats. On the other hand, pretreatment with dopamine antagonists (haloperidol 5.0, sulpiride 1.0, domperidone 5.0 mg/kg i.p.) significantly aggravated these lesions. Cimetidine markedly diminished the ulcerogenic effect of haloperidol but not that of domperidone, suggesting a brain-mediated site for the protective interaction of cimetidine and dopamine systems.

Izvorni jezik
Engleski



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Citiraj ovu publikaciju

Grabarević, Željko; Rotkvić, Ivica; Sikirić, Predrag; Seiwerth, Sven; Džaja, Petar; Perić, Josip; Kos, Josip
Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats // Acta veterinaria Hungarica, 45 (1997), 1; 85-93 (međunarodna recenzija, članak, znanstveni)
Grabarević, Ž., Rotkvić, I., Sikirić, P., Seiwerth, S., Džaja, P., Perić, J. & Kos, J. (1997) Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats. Acta veterinaria Hungarica, 45 (1), 85-93.
@article{article, year = {1997}, pages = {85-93}, keywords = {Interaction, protective effect, dopaminergic system, cimetidine, dopamine agonists and antagonists, haemorrhagic gastric lesionso}, journal = {Acta veterinaria Hungarica}, volume = {45}, number = {1}, title = {Brain-mediated protective interactions of histaminergic H2 and dopaminergic systems in rats}, keyword = {Interaction, protective effect, dopaminergic system, cimetidine, dopamine agonists and antagonists, haemorrhagic gastric lesionso} }

Časopis indeksira:


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  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI