Value of the urinary stone promoters/inhibitors ratios in the estimation of the risk of urolithiasis (CROSBI ID 86282)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Batinić, Danica ; Milošević, Danko ; Blau, Nenad ; Konjevoda, Paško ; Štambuk, Nikola ; Barbarić, Vesna ; Šubat-Dežulović, Mirna ; Votava-Raić, Ana ; Nižić, Ljiljana ; Vrljičak, Kristina
engleski
Value of the urinary stone promoters/inhibitors ratios in the estimation of the risk of urolithiasis
An imbalance between urinary-promoting and -inhibiting factors has been suggested as more important in urinary stone formation than a disturbance of any single substance. To investigate the value of promoter/inhibitor ratios for estimation of the risk of urolithiasis, urinary citrate/calcium, magnesium/calcium oxalate, and oxalate/citrate x glycosaminoglycans rtios were determined in 30 children with urolithiasis, 36 children with isolated hematuria, and 15 healthy control children. The cutoff points between normal children and children with urolithiasis, accuracy, specificity, and sensitivity for each ratio were determined and compared with those of the 24-h urine calcium and oxalate excretion and urine saturation calculated with the computer program EQUIL 2. The neural network application (aiNET Artificial Neural Network, version 1.25) was used for the determination of the cutoff points for the classification of normal children and the urolithiasis group. The best test for differentiating stone formers from non-stone formers proved the aiNET determined cutoff values of oxalate/citrate x glycosaminoglycans ratio. The method showed 97.78% accuracy, 100% sensitivity, and 93.33% specificity. Two cutoff points between normal and urolithiasis groups were found showing that the children with urolithiasis had ratio values either above 34.00 or less than 10.16. Increased oxalate excretion was linked to the first cutoff value (34.00), and decreased glycosaminoglycans excretion was typical of the second cutoff value (10.16).
calcium-oxalate ; computer-program ; saturation ; crystallization ; urolithiasis ; Equil2 ; tract
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Podaci o izdanju
40 (3)
2000.
607-610
objavljeno
0095-2338
10.1021/ci990076i
Povezanost rada
Temeljne medicinske znanosti