Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 389882

Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation


Rajić, Zrinka; Kos, Gabrijela; Zorc, Branka; Singh, Prati Pal; Singh, Savita
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation // Acta pharmaceutica, 59 (2009), 107-115 doi:10.2478/v10007-009-0007-x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 389882 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation

Autori
Rajić, Zrinka ; Kos, Gabrijela ; Zorc, Branka ; Singh, Prati Pal ; Singh, Savita

Izvornik
Acta pharmaceutica (1330-0075) 59 (2009); 107-115

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primaquine; polymer-drug conjugate; polyaspartamide; glucosamine; antimalarial activity

Sažetak
New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type poly  ,  -(N-2-hydroxyethyl-DL-aspartamide) (PHEA) and poly  ,  -(N-3-hydroxypropyl-DL-aspartamide) (PHPA) were synthesized, characterized and screened for their antimalarial activity. The conjugates differed in type of covalent bounding, length of spacer between the polymeric carrier and drug, molecular masses and drug-loading. Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice. Polymeric conjugates showed better antimalarial activity than the glucosamine conjugate.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
3917 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, MZOS)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Zrinka Rajić (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Kos, Gabrijela; Zorc, Branka; Singh, Prati Pal; Singh, Savita
Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation // Acta pharmaceutica, 59 (2009), 107-115 doi:10.2478/v10007-009-0007-x (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Kos, G., Zorc, B., Singh, P. & Singh, S. (2009) Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation. Acta pharmaceutica, 59, 107-115 doi:10.2478/v10007-009-0007-x.
@article{article, year = {2009}, pages = {107-115}, DOI = {10.2478/v10007-009-0007-x}, keywords = {primaquine, polymer-drug conjugate, polyaspartamide, glucosamine, antimalarial activity}, journal = {Acta pharmaceutica}, doi = {10.2478/v10007-009-0007-x}, volume = {59}, issn = {1330-0075}, title = {Macromolecular prodrugs: XII. Primaquine conjugates: Synthesis and preliminary antimalarial evaluation}, keyword = {primaquine, polymer-drug conjugate, polyaspartamide, glucosamine, antimalarial activity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font