Radiation-induced chromosomal aberrations and haematological alterations in hospital workers (CROSBI ID 86260)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Rozgaj, Ružica ; Kašuba, Vilena ; Šentija, Karmela ; Prlić, Ivica
engleski
Radiation-induced chromosomal aberrations and haematological alterations in hospital workers
Long-term exposure to low doses of ionizing radiation may affect cells and tissues and result in various adverse health effects. The purpose of this study was to investigate weather chromosome aberrations and haematological alterations could be used as biomarkers of possible radiation injury in workers expposed to ionizing radiation. Groups totalling 323 medical professionals handling X-ray equipment and 160 control subjects were examined for incidence of chromosome aberrations and changes in leukocyte, lymphocyte and thrombocyte counts. The incidence of all types of chromosome aberrations was higher in the expposed groups than in controls, yet no significant difference was found between the exposed groups. A many-fold increase in chromosome aberration frequency in all exposed groups was not followed by a corresponding haematological depression. This suggests that chromosome aberrations are a significantly more sensitive indicator of changes caused by low doses of ionizing radiation than haematological alterations.
blood count; chromosome aberrations; ionizing radiation; occupational exposure
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