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Pregled bibliografske jedinice broj: 38931

Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems


Ramljak, Sanja; Hackenberger, Branimir; Smital, Tvrtko; Britvić, Smiljana
Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems // Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 35 (2000), 6; 751-770 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 38931 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems

Autori
Ramljak, Sanja ; Hackenberger, Branimir ; Smital, Tvrtko ; Britvić, Smiljana

Izvornik
Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes (0360-1234) 35 (2000), 6; 751-770

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dicuran 500 FL; chlortoluron; genotoxicity; Ames test; micronucleus test; MFO; EROD; BaPMO; inhibition; fish

Sažetak
The effect of the herbicide Dicuran 500 FL (formulated product) on the phenotypical and genotypical changes in procaryotic and eucaryotic organisms was investigated using short-term tests for detecting genotoxins. Since pesticides discharged in the water environment can modulate the mixed-function monooxygenases (MFO) detoxification system of water organisms, the in vivo and in vitro effects of Dicuran on hepatic cytochrome P450 (cyt P450) monooxygenase activities were also examined in juvenile carp (Cyprinus carpio L.). By measuring the activities of MFO in experimental carp exposed to Dicuran an attempt was made to establish whether Dicuran could be bioactivated by MFO into ultimate mutagens. Our results on the bacterial strains Salmonella typhimurium TA100 and TA98 show that Dicuran does not possess either mutagenic or premutagenic characteristics. The micronucleus test on the erythrocytes of experimental carp did not establish any clastogenic effect either. However, Dicuran significantly inhibited the MFO activity of 7-ethoxyresorufin-O-deethylase (EROD) and benzo[a]pyrene monooxygenase (BaPMO) in the liver of experimental carp in vitro, as well as in in vivo conditions. These findings demonstrate the potentially damaging effect of Dicuran on the xenobiotic metabolizing enzyme systems of fish, and suggest the applicability of described methods for the prediction of the ecotoxicological significance of the presence of pesticides in the water environment.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
00981510
0101066
221360

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju

Ramljak, Sanja; Hackenberger, Branimir; Smital, Tvrtko; Britvić, Smiljana
Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems // Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 35 (2000), 6; 751-770 (međunarodna recenzija, članak, znanstveni)
Ramljak, S., Hackenberger, B., Smital, T. & Britvić, S. (2000) Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems. Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 35 (6), 751-770.
@article{article, year = {2000}, pages = {751-770}, keywords = {Dicuran 500 FL, chlortoluron, genotoxicity, Ames test, micronucleus test, MFO, EROD, BaPMO, inhibition, fish}, journal = {Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes}, volume = {35}, number = {6}, issn = {0360-1234}, title = {Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems}, keyword = {Dicuran 500 FL, chlortoluron, genotoxicity, Ames test, micronucleus test, MFO, EROD, BaPMO, inhibition, fish} }
@article{article, year = {2000}, pages = {751-770}, keywords = {Dicuran 500 FL, chlortoluron, genotoxicity, Ames test, micronucleus test, MFO, EROD, BaPMO, inhibition, fish}, journal = {Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes}, volume = {35}, number = {6}, issn = {0360-1234}, title = {Evaluation of the genotoxic and cytochrome P450 monooxigenase-inhibitory potential of Dicuran on procaryotic and eucaryotic test systems}, keyword = {Dicuran 500 FL, chlortoluron, genotoxicity, Ames test, micronucleus test, MFO, EROD, BaPMO, inhibition, fish} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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