Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with the risk for alcohol dependence (CROSBI ID 86249)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Lichtermann, D. ; Hranilović, Dubravka ; Trixler, M. ; Franke, P. ; Jernej, Branimir ; Delmo, C.D. ; Knapp, M. ; Schwab, S.G. ; Maier, W. ; Wildenauer, D.B.
engleski
Support for allelic association of a polymorphic site in the promoter region of the serotonin transporter gene with the risk for alcohol dependence
An association between the 5-HTTLPR short variant polymorphism in the promoter region of the serotonin transporter gene and risk for alcohol dependence has been reported from case-control studies that are, however, prone to chance findings related to artifacts of population structure. The authors sought additional evidence for this association from a family based study. 92 alcohol-dependent probands and their parents were tested for nonrandom transmission of alleles from heterozygous parents to affected probands. Preferential transmission of the short allele was found (65 of 102 transmissions from heterozygous parents). The results suggest allelic association between a variant in the promoter region of the serotonin transporter gene and the risk for alcohol dependence. However, it remain to be seen whether the functional properties of this variant are directly responsible for the increased risk to alcohol dependence.
alleles; serotonin transporter gene; alcohol dependence
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
157 (12)
2000.
2045-2047
objavljeno
0002-953X
1535-7228
10.1176/appi.ajp.157.12.2045
Povezanost rada
Temeljne medicinske znanosti