Expression of FasL molecule in acute and chronic psoriatic plaque (CROSBI ID 546776)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Prpić Massari, Larisa ; Kaštelan, Marija ; Gruber, Franjo ; Zamolo, Gordana ; Žauhar, Gordana ; Rukavina, Daniel
engleski
Expression of FasL molecule in acute and chronic psoriatic plaque
Psoriasis is autoimmune skin diseas in which keratinocyte proliferation was initiated by T cell infiltration and activation. Among T cells, CD4+ T cell predominance in exacerbated psoriatic plaques and CD8+ T cells in resolutive lesions are demonstrated. Cell mediated cytotoxicity reactions (CMC) are mediated by perforin and granzyme exocytosis or binding of FasL (CD95L) with Fas receptor (CD95) on target cell. CD8+ T lymphocytes and to a certain degree CD4+ T lymphocytes as well as NK cells mediate in CMC. The role of cytolytic Fas/FasL pathway is recognized in psoriasis but still insufficiently defined. The aim of our investigation was to analyze expression of Fas and FasL molecules in the psoriatic skin lesions and highlight a role of cytotoxicity mediated by this pathway in pathophysiology of disease.
FasL molecule; expression; acute psoriatic plaque; chronic psoriatic plaque
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
2003.
objavljeno
Podaci o matičnoj publikaciji
Podaci o skupu
6th Alpe Adria Symposium on Psoriasis
poster
07.11.2003-08.11.2003
Venecija, Italija; Bibione, Italija