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Changes in the quantity of cathepsin D in irradiated human cells following treatment with hyperthermia and interferon

In the present work, the changes in quantity of cathepsin D, an aspartic proteinase, in proliferating human nonmalignant (HEF) and malignant (HEP2) cells after combined treatment by gamma irradiation, hyperthermia and by interferon α -2b (IFN α ) were analyzed. Correlation between the antiproliferative effects of these combined agents in the concentrations of this cathepsin D was expected. Evidently, the treatment of cells in culture by IFNα , combined with irradiation and elevated temperature, produces an increased quantity of cathepsin D. In nonmalignant HEF cells these effects are more expressed than in malignant Hep2 cells.

cathepsin D; irradiated human cells; treatment; hyperthermia; interferon

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