engleski

Genetic thrombophilia and pregnancy complications

At least one thrombophilic mutation was observed in 41.6% of women with pregnancy complications vs. to 20.6% of women with normal pregnancies (p=0.003), factor V Leiden was observed in 15.8% cases and 7.8% controls, prothrombin 20210A in 5.9% cases and 2.9% controls and homozygosity for MTHFR 677T, in 19.8% cases and 9.8% controls. Double and triple thrombophilic mutations were detected in 6.9% women with pregnancy complications compared to none in the control group. Women with severe pregnancy complications and related venous thromboembolism have an increased frequency of genetic thrombophilic mutations.

Pregnancy complications; Factor V Leiden; prothrombin 20210G; MTHFR 677C

Rad je prikazan kao kongresno priopćenje na 7th International Symposium on Molecular Diagnostics, Medical University of Graz, Austria, May 22 – 24 2008 (A65)i štampan u Clin Chem Lab Med 2008 ; 46(4):45– A66 (Walter de Gruyter • Berlin • New York. DOI 10.1515/CCLM.2008.05)