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THE EARLY PREDICTION OF DEVELOPMENT OF ATHEROSCLEROSIS IN PRE-DIABETES PATIENTS - FERRITIN/FOLATE INDEX.

Background: Recent studies had shown that early phases of diabetes development is associated with oxidative stress and atherosclerosis. In type 2 diabetes atherosclerosis development have been related with high ferritin and low folate levels. The aim of this study is to investigate contribution of these two parameters on development of atherosclerosis in early phases of diabetes (pre-diabetes). Patients and Methods: This study included over random sample of 52 patients: 17 male (34%) i 34 females (66%). They were separated in two groups: group N &#8211; patients with normoglycaemia and group D - patients with prediabetes (45%). Results: 52 patients were examined ; mean age of group N=63, 42&plusmn ; 10, 9 years ; group D=64, 54&plusmn ; 8, 9 years. Values of HBA1C were in group N=4, 67%&plusmn ; 0, 3 ; in group D=4, 96%&plusmn ; 0, 4 ; ferritin in group N=74, 1&#956; g/mL&plusmn ; 18, 2 ; in group D=134, 1&#956; g/mL&plusmn ; 16, 2. The levels of folate were in group N=10, 9&#956; g/mL&plusmn ; 6, 2 ; in group D=8, 1&#956; g/mL&plusmn ; 3, 2. The results indicated statisticaly higher index ferritin / folat (p<0, 008) in group D - patients with prediabetes. Conclusions: Index ferritin / folat can suggests a high probability for atherosclerosis development in early phases of diabetes (pre-diabetes). It is simple screening test in routine clinical practice for determination of possible atherosclerosis development in risk patients.

pre-diabetes; index ferritin / folat; atherosclerosis development

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