engleski

Chromosomal aberrations and frequency of micronuclei in workers employed in pesticide production

The possible genotoxic effects of occupational exposure to complex pesticide mixture in workers employed in pesticide production were studied. Two different cytogenetic assays on cultured peripheral blood lymphocytes were used: the analysis of structural chromosomal aberrations and micronucleus assay. A significantly increased number of chromatid and chromosome breaks as well as the presence of dicentric chromosomes and chromatid exchanges (tetraradii) in exposed subjects regarding to the control subjects (P<0.05)were recorded. There was also statistically significant difference in frequency and distribution of micronuclei between the two groups examined (exposed and control). These results suggest that occupational exposure to pesticides could be able of causing genome damages in somatic cells.

chromosomal aberrations; micronucleus assay; pesticides; occupational exposure; human lymphocytes

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