engleski

Polymorphism of HLA-DQ alleles in Croatian patients with psoriasis

In this study, we have analysed the distribution of HLA- DQ alleles in type I and type II Croatian psoriatics by hibridization with specific oligonucleotide probes. Type I psoriasis showed significant association with DQA1*0201 (p 0.00001 ; RR=6.12), DQB1*0201 (p=0.0006 ; RR=3.29) and DQB1*0303 (p=0.0008 ; RR=7.51) alleles. A negative correlation with type I disease was observed for DQA1*0102 allele (p=0.002 ; RR=0.26). Patients with type II psoriasis did not show association with any HLA-DQ alleles. In conclusion, DQA1*0201, DQB1*0201 and DQB1*0303 alleles bear a significant risk for developing type I psoriasis in Croatian population.

polymorphism; HLA-DQ alleles; Croatian patients; psoriasis

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