engleski

FasL molecule is up-regulated in the epidermis of psoriatic lesion

The role of cell-mediated cytotoxicity in psoriasis is not yet understood. Cytotoxic CD8+ T cells mediate cytotoxic reactions mainly by two different pathways, perforin/granzyme and Fas/FasL pathway while CD4+ T cells preferentially use Fas/FasL system. In the present study we analyzed FasL expression in both, epidermis and dermis, of lesional psoriatic skin (n=9), non-lesional psoriatic skin (n=9) and healthy control (n=8) by immunohistochemistry using biotin-streptavidin-peroxidase method. In epidermis, we found a significant increase in CD4+ and CD8+ T cells in lesions compared with non-lesional and healthy epidermis. The expression of FasL was also significantly higher in the lesional compared with non-lesional epidermis. In addition, FasL expresion was almost two times higher in epidermis than in dermis of psoriatic lesions. In conclusion, our results clearly point out the potential role of FasL cytolytic pathway in the development of psoriatic plaque.

FasL molecule; epidermis; T cells; psoriasis

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