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Perforin expression is increased in the psoriatic lesions


Kaštelan, Marija; Prpić Masarri, Larisa; Zamolo, Gordana; Žauhar, Gordana; Čoklo, Miran; Gruber, Franjo
Perforin expression is increased in the psoriatic lesions // European Congress on Psoriasis : abstracts ; u: Journal of the European Academy of Dermatology and Venereology
Pariz, Francuska, 2004. str. 811-811 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Perforin expression is increased in the psoriatic lesions

Autori
Kaštelan, Marija ; Prpić Masarri, Larisa ; Zamolo, Gordana ; Žauhar, Gordana ; Čoklo, Miran ; Gruber, Franjo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Congress on Psoriasis : abstracts ; u: Journal of the European Academy of Dermatology and Venereology / - , 2004, 811-811

Skup
European Congress on Psoriasis

Mjesto i datum
Pariz, Francuska, 21.-24.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Psoriasis; NK cells; perforin

Sažetak
The role of cell cytotoxicity mediated by cytotoxic CD8+ T lymphocytes and NK cells in the pathogenesis of psoriasis is still not clear. Cytotoxic T and NK cells mediate cytotoxic reactions mainly by perforin/granzyme and Fas/FasL pathway. Objective was to investigate the expression of perforin molecule, T and NK cells in the psoriatic lesions. Skin biopsy specimens from lesional and non-lesional skin of 11 patients with chronic plaque psoriasis and 8 healthy persons were analysed by immunohistochemistry. Significant increase in whole T cell population, particularly in CD4+ and CD8+ cells were observed in the lesional epidermis and dermis compared with non-lesional (p<0.001)and healthy control (p<0.01). The expression of CD16+ NK cells was significantly lower in lesions compared with healthy skin (p<0.05). Perforin expression was significantly increased in the epidermis of psoriatic lesions (p<0.01). Our data clearly showed the accumulation of CD4+ and CD8+ T cells in psoriatic lesions suggesting a functional interaction of both subsets in creating and maintaining the psoriatic plaque. Increased perforin expression in the epidermis of psoriatic lesions suggest a potential role of this cytolytic pathway in the development of psoriatic plaque.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0062040

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE