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Pregled bibliografske jedinice broj: 386838

An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease


Kraljević Pavelić, Sandra; Sedić, Mirela; Hock, Karlo; Vučinić, Srđan; Jurišić, Davor; Gehrig, Peter; Scott, Mike; Schlapbach, Ralph; Čačev, Tamara; Kapitanović, Sanja; Pavelić, Krešimir
An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease // Journal of Pathology, 217 (2009), 4; 524-533 doi:10.1002/path.2483 (međunarodna recenzija, članak, znanstveni)


Naslov
An integrated proteomics approach for studying the molecular pathogenesis of Dupuytren's disease

Autori
Kraljević Pavelić, Sandra ; Sedić, Mirela ; Hock, Karlo ; Vučinić, Srđan ; Jurišić, Davor ; Gehrig, Peter ; Scott, Mike ; Schlapbach, Ralph ; Čačev, Tamara ; Kapitanović, Sanja ; Pavelić, Krešimir

Izvornik
Journal of Pathology (0022-3417) 217 (2009), 4; 524-533

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Akt; bioinformatics; cytoskeleton; Dupuytren's disease; proteomics

Sažetak
Dupuytren's disease (DD) is a fibromatosis characterized by non-malignant transformation of palmar fascia leading to permanent contraction of one or more fingers. Despite the extensive knowledge of its clinical pathogenesis, the aetiology of this disease remains obscure. In the present paper, we report for the first time on the proteomic profiling of diseased versus unaffected patient-matched palmar fasciae tissues from DD patients using two-dimensional gel electrophoresis coupled with mass spectrometry analysis. The herein identified proteins were then used to create the protein-protein interaction network (interactome). Such an integrated approach revealed the involvement of several different molecular processes related to DD progression, including extra- and intra-cellular signalling, oxidative stress, cytoskeletal changes, and alterations in cellular metabolism. In particular, autocrine regulation through ERBB-2 and IGF-1R receptors and the Akt signalling pathway have emerged as novel components of pro-survival signalling in Dupuytren's fibroblasts and thus might provide a basis for a new therapeutic strategy in Dupuytren's disease.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Sanja Kapitanović, )
101-0982464-2277 - Molekularno profiliranje metastazirajućeg tumora dojke (Dragan Dekaris, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Hrvatska akademija znanosti i umjetnosti

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • AGRICOLA
  • BIOSIS Previews (Biological Abstracts)
  • CAB Abstracts
  • EMBASE (Excerpta Medica)


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