engleski

Are neonatal jaundice, heart murmur, dyslalia and learning/ memory impairments consequences of mother exposure to environmental oxidants?

Methemoglobin and hemolysis are both the result of oxidative stress, but the difference between them is that methemoglobin is a reversible phenomenon whereas hemolysis is not, as it affects the membrane of the red blood cell. The objective of this review is to direct attention to methemoglobin toxic effects of oxidative stress, which puts pregnancy at risk and may later impair the health of newborns, children and adolescents. In our investigation of pregnant women (n=36) whose methemoglobin level was >1.5 g/L, we took blood samples from newborns and followed them up by collecting health data from perinatal hospital departments, the preschool office and school service at the health center for up to eighteen years. The incidences of neonatal jaundice (p=0.034) and later heart murmur (p=0.011), and dyslalia and learning / memory impairments (p=0.002) were significantly higher than in children of control mothers (n=19). We found that mothers with methemoglobinemia were exposed to airborne oxidants (sulfur dioxide, nitrogen oxides, nitrogen dioxide, nitric oxide) which confirmed our suspicion of "fetal preeclampsia", because these oxidants have the capacity to cross the placental barrier. Depending on the mother's exposure to environmental oxidants, the fetus during the development is more readily affected by methemoglobin and hemolysis. Posited researches confirm our thesis on the pathophysiological relationship between methemoglobinemia and unexplained jaundice and hyperbilirubinemia as a later heart murmur, dyslalia and learning and memory impairments which has not exactly been demonstrated yet.

pregnancy risk; environmental oxidants; fetal development; methemoglobin as biomarker; impaired health; newborns; children; adolescents

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