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Pregled bibliografske jedinice broj: 386055

Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen


Novak, Predrag; Tepeš, Predrag; Ilijaš, Marina; Fistrić, Ines; Bratoš, Igor; Avdagić, Amir; Hameršak, Zdenko; Gabelica Marković, Vesna; Dumić, Miljenko
Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen // Journal of Pharmaceutical and Biomedical Analysis, 50 (2009), 1; 68-72 doi:10.1016/j.jpba.2009.03.017 (međunarodna recenzija, članak, znanstveni)


Naslov
Rapid LC-NMR and LC-MS characterization of an unknown component in a novel antifungal drug Icofungipen

Autori
Novak, Predrag ; Tepeš, Predrag ; Ilijaš, Marina ; Fistrić, Ines ; Bratoš, Igor ; Avdagić, Amir ; Hameršak, Zdenko ; Gabelica Marković, Vesna ; Dumić, Miljenko

Izvornik
Journal of Pharmaceutical and Biomedical Analysis (0731-7085) 50 (2009), 1; 68-72

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Icofungipen; impurity; liquid chromatography - nuclear magnetic resonance spectroscopy; liquid chromatography - mass spectrometry
(Cofungipen; impurity; liquid chromatography - nuclear magnetic resonance spectroscopy; liquid chromatography - mass spectrometry)

Sažetak
A successful use of LC-NMR and LC-MS for a rapid identification of the unknown component in a novel antifungal drug Icofungipen has been demonstrated. Complementary information obtained from the two methods made it possible to identify and determine the structure of A1 prior to its isolation and purification. The analysis of the stop-flow LC-NMR (1H and DQFCOSY), LC-MS and LC-MS/MS spectra has shown that A1 is structurally related to Icofungipen. The impurity A1 was later isolated and prepared synthetically and its structure was corroborated by high-resolution NMR spectroscopy. The combined use of LC-NMR and LC-MS methodology as described here can serve as an efficient, fast and reliable tool for determination of the Icofungipen impurities in the following production process.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )
098-0982933-2908 - Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost (Zdenko Hameršak, )
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Predrag Novak, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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