Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer (CROSBI ID 148279)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Kovač, Dražen ; Rubinić, Milivoj ; Krašević, Maja ; Križanac, Šimun ; Petrovečki, Mladen ; Štimac, Davor ; Melato, M.
engleski
Proliferating cell nuclear antigen (PCNA) as a prognostic factor for colorectal cancer
PCNA (proliferating cell nuclear antigen) is a cell cycle related protein that is maximally elevated in late G1 and S-phase of proliferating cells. 114 biopsy specimens of colorectal cancer were immunolabeled with PC 10 which specifically recognizes PCNA ; Dukes' staging and histological grading were estimated for each case. All patients were followed-up for at least 60 months or to death. All data were analysed by the computer program NCSS (Number Cruncher Statistical System). According to the results, PCNA-index may be considered an independent prognostic factor for colorectal cancer ; it may also be helpful in supporting the therapeutic strategies based only on Dukes' stage.
PCNA ; Cell proliferation ; Colorectal cancer
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