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Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2 (CROSBI ID 148228)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Maier, Sabine ; Staffler, Gabriele ; Hartmann, Andrea ; Höck, Julia ; Henning, Karen ; Grabušić, Kristina ; Mailhamme, Reinhard ; Hoffmann, Reinhard ; Wilmanns, Matthias ; Lang, Roland et al. Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2 // Journal of virology, 80 (2006), 19; 9761-9771

Podaci o odgovornosti

Maier, Sabine ; Staffler, Gabriele ; Hartmann, Andrea ; Höck, Julia ; Henning, Karen ; Grabušić, Kristina ; Mailhamme, Reinhard ; Hoffmann, Reinhard ; Wilmanns, Matthias ; Lang, Roland ; Mages, Jörg ; Kempkes, Bettina

engleski

Cellular Target Genes of Epstein-Barr Virus Nuclear Antigen 2

Epstein-Barr virus (EBV) nuclear antigen 2 (EBNA-2) is a key determinant in the EBV-driven B-cell growth transformation process. By activating an array of viral and cellular target genes, EBNA-2 initiates a cascade of events which ultimately cause cell cycle entry and the proliferation of the infected B cell. In order to identify cellular target genes that respond to EBNA-2 in the absence of other viral factors, we have performed a comprehensive search for EBNA-2 target genes in two EBV-negative B-cell lines. This screen identified 311 EBNA-2-induced and 239 EBNA-2-repressed genes that were significantly regulated in either one or both cell lines. The activation of most of these genes had not previously been attributed to EBNA-2 function and will be relevant for the identification of EBNA-2-specific contributions to EBV-associated malignancies. The diverse spectrum of EBNA-2 target genes described in this study reflects the broad spectrum of EBNA-2 functions involved in virus-host interactions, including cell signaling molecules, adapters, genes involved in cell cycle regulation, and chemokines.

Epstein-Barr virus; nuclear antigen 2; B cells; transformation

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Podaci o izdanju

80 (19)

2006.

9761-9771

objavljeno

0022-538X

Povezanost rada

Biologija

Indeksiranost