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Pregled bibliografske jedinice broj: 3849

Met-enkephalin modulates stress-induced alterations of the immune response in mice


Marotti, Tanja; Gabrilovac, Jelka; Rabatić, Sabina; Smejkal-Jagar, Lidija; Ročić, Boris; Haberstock, Helena
Met-enkephalin modulates stress-induced alterations of the immune response in mice // Pharmacology, biochemistry and behavior, 54 (1996), 1; 277-284 doi:10.1016/0091-3057(95)02112-4 (međunarodna recenzija, članak, znanstveni)


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Naslov
Met-enkephalin modulates stress-induced alterations of the immune response in mice

Autori
Marotti, Tanja ; Gabrilovac, Jelka ; Rabatić, Sabina ; Smejkal-Jagar, Lidija ; Ročić, Boris ; Haberstock, Helena

Izvornik
Pharmacology, biochemistry and behavior (0091-3057) 54 (1996), 1; 277-284

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
met-enkephalin ; stress ; immune response ; naloxone ; hpa axis

Sažetak
Overnight restraint stress of mice decreased ConA-driven lymphocyte proliferation, plaque-forming cell response to sheep red blood cells (SRBC), and NK activity in the spleen, but the phagocytic activity was enhanced. Injection of methionine-enkephalin (MENK), 10 mg/kg, IP, 30 min before restraint, abolished these changes (except for the NK activity) and attenuated the stress-induced elevation of glucocorticoids. However, MENK itself affected the immune responses like stress: It decreased NK activity and the PFC response and enhanced phagocytic activity. Contrary to results with stress, MENK had no effect on cell proliferation. The opioid-receptor antagonist naloxone given before restraint reversed the stress-induced enhancement of phagocytosis and the decrease of T-cell proliferation. Alterations of the immune responses induced by restraint stress seem to be mediated by at least two mechanisms: activation of the hypothalamus-pituitary-adrenal (HPA) axis and the secretion of opioid peptides. MENK injected before stress may interfere with either or both mechanisms. T or B lymphocytes seem to be affected by the activation of the HPA axis, and phagocytes by a direct opioid action, whereas NK cells seem to be under the influence of another control mechanism. [References: 46]

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita, Farmacija



POVEZANOST RADA


Ustanove:
Imunološki zavod d.d.,
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac,
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Marotti, Tanja; Gabrilovac, Jelka; Rabatić, Sabina; Smejkal-Jagar, Lidija; Ročić, Boris; Haberstock, Helena
Met-enkephalin modulates stress-induced alterations of the immune response in mice // Pharmacology, biochemistry and behavior, 54 (1996), 1; 277-284 doi:10.1016/0091-3057(95)02112-4 (međunarodna recenzija, članak, znanstveni)
Marotti, T., Gabrilovac, J., Rabatić, S., Smejkal-Jagar, L., Ročić, B. & Haberstock, H. (1996) Met-enkephalin modulates stress-induced alterations of the immune response in mice. Pharmacology, biochemistry and behavior, 54 (1), 277-284 doi:10.1016/0091-3057(95)02112-4.
@article{article, year = {1996}, pages = {277-284}, DOI = {10.1016/0091-3057(95)02112-4}, keywords = {met-enkephalin, stress, immune response, naloxone, hpa axis}, journal = {Pharmacology, biochemistry and behavior}, doi = {10.1016/0091-3057(95)02112-4}, volume = {54}, number = {1}, issn = {0091-3057}, title = {Met-enkephalin modulates stress-induced alterations of the immune response in mice}, keyword = {met-enkephalin, stress, immune response, naloxone, hpa axis} }
@article{article, year = {1996}, pages = {277-284}, DOI = {10.1016/0091-3057(95)02112-4}, keywords = {met-enkephalin, stress, immune response, naloxone, hpa axis}, journal = {Pharmacology, biochemistry and behavior}, doi = {10.1016/0091-3057(95)02112-4}, volume = {54}, number = {1}, issn = {0091-3057}, title = {Met-enkephalin modulates stress-induced alterations of the immune response in mice}, keyword = {met-enkephalin, stress, immune response, naloxone, hpa axis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • Index Medicus


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