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Pregled bibliografske jedinice broj: 38394

Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report


Šprem, Marina; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez; Osmak, Maja
Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report // Radiology and oncology, 34 (2000), 1; 41-47 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 38394 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report

Autori
Šprem, Marina ; Babić, Damir ; Abramić, Marija ; Miličić, Duško ; Vrhovec, Ivan ; Škrk, Janez ; Osmak, Maja

Izvornik
Radiology and oncology (1318-2099) 34 (2000), 1; 41-47

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ovarian neoplasms; cathepsin D; plasminogen activator inhibitor type 1

Sažetak
Background. The aim of the present study was to determine the concentration of cathepsin D (Cath D) and plasminogen activator inhibitor type 1 (PAI-1) in normal ovarian tissue, benign and malignant ovarian tumor tissues and to asses relationship between Cath D and PAI-1 content, and some clinical and pathohistological parameters. Materials and methods. Cath D contents and PAI-1 concentrations were determined (using immunoradiometric ELSA-Cath D assay and commercial IMUDINDR ELISA immunoassay, respectively) in 35 samples: 10 normal ovarii, 10 benign, 10 primary malignant and 5 metastatic ovarian tumors. Results. The concentrations of Cath D were significantly higher in malignant (32.89ą14.26 pmol/mg protein ) and metastatic (31.42 ą10.24 pmol/mg protein) than in normal (13.68ą4.03 pmol/mg protein) and benign (17.89ą13.13 pmol/mg protein) ovarian tissues. There was no statistical differences in the concentrations of PAI-1 between normal, benign, malignant and metastatic tumor specimens. The concentration of cathepsin D as well as PAI-1 did not correlated to age of patients, menopausal status, parity, GOG risk group, clinical stage or pathohistological grading. Conclusion. Concentrations of Cath D ( but not PAI-1) were significantly increased in malignant ovarian tumor tissues when compared to normal and benign ovarian tumor samples; they were independent from examined pathohistological and clinical parameters.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Marija Abramić (autor)

Avatar Url Maja Osmak (autor)

Avatar Url Damir Babić (autor)

Avatar Url Duško Miličić (autor)


Citiraj ovu publikaciju:

Šprem, Marina; Babić, Damir; Abramić, Marija; Miličić, Duško; Vrhovec, Ivan; Škrk, Janez; Osmak, Maja
Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report // Radiology and oncology, 34 (2000), 1; 41-47 (međunarodna recenzija, članak, znanstveni)
Šprem, M., Babić, D., Abramić, M., Miličić, D., Vrhovec, I., Škrk, J. & Osmak, M. (2000) Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report. Radiology and oncology, 34 (1), 41-47.
@article{article, year = {2000}, pages = {41-47}, keywords = {ovarian neoplasms, cathepsin D, plasminogen activator inhibitor type 1}, journal = {Radiology and oncology}, volume = {34}, number = {1}, issn = {1318-2099}, title = {Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report}, keyword = {ovarian neoplasms, cathepsin D, plasminogen activator inhibitor type 1} }
@article{article, year = {2000}, pages = {41-47}, keywords = {ovarian neoplasms, cathepsin D, plasminogen activator inhibitor type 1}, journal = {Radiology and oncology}, volume = {34}, number = {1}, issn = {1318-2099}, title = {Cathepsin D and plasminogen activator inhibitor type 1 in normal, benign and malignant ovarian tissues: a preliminary report}, keyword = {ovarian neoplasms, cathepsin D, plasminogen activator inhibitor type 1} }

Časopis indeksira:


  • Scopus


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