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Platelet serotonin level in rats is under genetic control (CROSBI ID 147582)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jernej, Branimir ; Čičin-Šain, Lipa Platelet serotonin level in rats is under genetic control // Psychiatry research, 32 (1990), 2; 167-174. doi: 10.1016/0165-1781(90)90083-H

Podaci o odgovornosti

Jernej, Branimir ; Čičin-Šain, Lipa

engleski

Platelet serotonin level in rats is under genetic control

It has recently been shown that platelet serotonin (5-hydroxytryptamine, 5HT) levels (PSL) in Wistar rats represent an individually stable biological parameter (neither subject to periodic oscillations nor markedly influenced by sex and age) that shows a unimodal frequency distribution within the population (range: 1.2-2.2 μ g 5HT/mg platelet protein). To investigate the genetic background of PSL, selective breeding for the extreme values of this trait was performed. In the fourth generation, two discrete sublines of animals (statistically different from the unselected population) with constitutionally high or low PSL could be discerned: one with congenitally low PSL (1.1-1.6 μ g 5HT/mg platelet protein ; approximately normal distribution) and the other with congenitally high PSL (1.6-2.9 μ g 5HT/mg platelet protein ; irregular distribution). No difference in the pattern of inheritance between sexes could be discerned. The results demonstrated a marked heritable component underlying the expression of individual values of PSL in rats, suggesting that this parameter is a trait characteristic.

platelet serotonin ; selective breeding ; trait characteristic ; genetic control ; hyperserotonemia

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Podaci o izdanju

32 (2)

1990.

167-174

objavljeno

0165-1781

10.1016/0165-1781(90)90083-H

Povezanost rada

Biologija, Temeljne medicinske znanosti

Poveznice
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