engleski

Physiological characteristics of platelet serotonin in rats

Physiological characteristics of platelet serotonin (5-HT) levels in rats of Wistar origin were investigated by use of a recently developed method. By comparison of populations of male and female rats (n=281) similar unimodal frequency distributions, with a tendency to higher values in females (1.61 vs. 1.70 μ g 5HT/mg platelet protein ; p<0.01), were found. For a group of 55 animals, monitored twice for this parameter within a week interval, a remarkable intraindividual constancy in time, the mean difference between two determinations being 5.5%, was shown. No age-dependence could be demonstrated for platelet serotonin concentrations in 5- to 30- week-old rats, nor were there significant circadian or seasonal oscillations.

serotonin ; platelet ; rat

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