Introduction of the gene amplification technology to decrease the risk of hepatitis C virus transmission by plasma products (CROSBI ID 86076)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Branović, Karmen ; Forčić, Dubravko ; Košutić-Gulija, Tanja ; Šantak, Maja ; Zgorelec, Renata ; Mažuran, Renata
engleski
Introduction of the gene amplification technology to decrease the risk of hepatitis C virus transmission by plasma products
The viral safety of plasma-derived products with respect to hepatitis C virus (HCV) is assured by selection of donors, screening of individual donations for antibodies to HCV and the incorporation of effective viral inactivation-removal steps into manufacturing processes. As antibody screening of single donations is not sufficient to completely eliminate HCV RNA positive plasmas from plasma pools, testing for HCV RNA by gene amplification techniques may be necessary to identify positive donors. Using modern molecular biology techniques, we developed a specific, sensitive and reproducible method for routine PCR screening for HCV RNA in plasma pools.
hepatitis C virus; viruses; RNA
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti