Napredna pretraga

Pregled bibliografske jedinice broj: 381455

Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids


Jones, Michael; Mercer, Amy E.; Stocks, Paul A.; La Pensée, Louise J. I.; Cosstick, Rick; Park, B. Kevin; Kennedy, Miriam E.; Piantanida, Ivo; Ward, Stephen A.; Davies, Jill et al.
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids // Bioorganic and Medicinal Chemistry Letters, 19 (2009), 7; 2033-2037 doi:10.1016/j.bmcl.2009.02.028 (međunarodna recenzija, članak, znanstveni)


Naslov
Antitumour and Antimalarial Activity of Artemisinin-Acridine Hybrids

Autori
Jones, Michael ; Mercer, Amy E. ; Stocks, Paul A. ; La Pensée, Louise J. I. ; Cosstick, Rick ; Park, B. Kevin ; Kennedy, Miriam E. ; Piantanida, Ivo ; Ward, Stephen A. ; Davies, Jill ; Bray, Patrick G. ; Rawe, Sarah L. ; Baird, Jonathan ; Charidza, Tafadzwa ; Janneh, Omar ; Stocks, Paul A. ; O’ Neill, Paul M.

Izvornik
Bioorganic and Medicinal Chemistry Letters (0960-894X) 19 (2009), 7; 2033-2037

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Artemisinin; acridine; antimalarial; anticancer; apoptosis; DNA; confocal microscopy

Sažetak
Artemisinin-acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2 to 4 fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Ivo Piantanida, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Autor s matičnim brojem:
Ivo Piantanida, (202026)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati