Hyperserotonemia in autism : activity of 5HT-associated platelet proteins (CROSBI ID 147376)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Hranilović, Dubravka ; Bujas-Petković, Zorana ; Tomičić, Maja ; Bordukalo-Nikšić, Tatjana ; Blažević, Sofia ; Čičin-Šain, Lipa
engleski
Hyperserotonemia in autism : activity of 5HT-associated platelet proteins
Disturbances in serotonin (5HT) neurotransmission have been indicated as biological substrates in several neuropsychiatric disorders including autism. Blood 5HT concentrations, elevated in about one third of autistic subjects, are regulated through the action of peripheral 5HT-associated proteins. We have measured the activity of two platelet 5HT-associated proteins: 5HT transporter (5HTT) and monoamine oxidase B (MAOB), and indirectly studied the activity of 5HT2A receptor (5HT2Ar) in 15 hyperserotonemic (HS) and 17 normoserotonemic (NS) autistic subjects, and 15 healthy controls (C). While mean velocities of 5HTT kinetics did not significantly differ among the groups, significant elevation in the mean velocity of MAOB kinetics was observed in NS subjects and was even more pronounced in HS subjects in comparison to controls. Also, a decrease in ADP-induced platelet aggregation of borderline significance was observed in NS subjects, compared to C subjects. The results suggest a possibility of upregulation of monoaminergic synthesis/degradation and, probably consequential, downregulation of 5HT2A receptors in autistic subjects.
autism ; hyperserotonemia ; 5HT uptake ; MAOB kinetics ; platelet aggregation ; adenosine diphosphate
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
116 (4)
2009.
493-501
objavljeno
0300-9564
1435-1463
10.1007/s00702-009-0192-2
Povezanost rada
Biologija, Temeljne medicinske znanosti, Biotehnologija