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Pregled bibliografske jedinice broj: 381195

Hyperserotonemia in autism : activity of 5HT-associated platelet proteins


Hranilović, Dubravka; Bujas-Petković, Zorana; Tomičić, Maja; Bordukalo-Nikšić, Tatjana; Blažević, Sofia; Čičin-Šain, Lipa
Hyperserotonemia in autism : activity of 5HT-associated platelet proteins // Journal of neural transmission, 116 (2009), 4; 493-501 doi:10.1007/s00702-009-0192-2 (međunarodna recenzija, članak, znanstveni)


Naslov
Hyperserotonemia in autism : activity of 5HT-associated platelet proteins

Autori
Hranilović, Dubravka ; Bujas-Petković, Zorana ; Tomičić, Maja ; Bordukalo-Nikšić, Tatjana ; Blažević, Sofia ; Čičin-Šain, Lipa

Izvornik
Journal of neural transmission (0300-9564) 116 (2009), 4; 493-501

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Autism; hyperserotonemia; 5HT uptake; MAOB kinetics; platelet aggregation; adenosine diphosphate

Sažetak
Disturbances in serotonin (5HT) neurotransmission have been indicated as biological substrates in several neuropsychiatric disorders including autism. Blood 5HT concentrations, elevated in about one third of autistic subjects, are regulated through the action of peripheral 5HT-associated proteins. We have measured the activity of two platelet 5HT-associated proteins: 5HT transporter (5HTT) and monoamine oxidase B (MAOB), and indirectly studied the activity of 5HT2A receptor (5HT2Ar) in 15 hyperserotonemic (HS) and 17 normoserotonemic (NS) autistic subjects, and 15 healthy controls (C). While mean velocities of 5HTT kinetics did not significantly differ among the groups, significant elevation in the mean velocity of MAOB kinetics was observed in NS subjects and was even more pronounced in HS subjects in comparison to controls. Also, a decrease in ADP-induced platelet aggregation of borderline significance was observed in NS subjects, compared to C subjects. The results suggest a possibility of upregulation of monoaminergic synthesis/degradation and, probably consequential, downregulation of 5HT2A receptors in autistic subjects.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Biotehnologija



POVEZANOST RADA


Projekt / tema
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )
098-1081870-2397 - Serotonergični mehanizmi u alkoholizmu (Lipa Čičin-Šain, )
119-1081870-2396 - Neurobiološka podloga autizma: uloga serotoninskog sustava (Dubravka Hranilović, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • EMBASE (Excerpta Medica)


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