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Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome


Knežević, Ana; Polašek, Ozren; Gornik, Olga; Rudan, Igor; Campbe, Harry; Hayward, Caroline; Wright, Alan; Kolčić, Ivana; O'Donoghue, Niaobh; Bones, Jonathan et al.
Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome // Journal of proteome research, 8 (2009), 2; 694-701 doi:10.1021/pr800737u (međunarodna recenzija, članak, znanstveni)


Naslov
Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome

Autori
Knežević, Ana ; Polašek, Ozren ; Gornik, Olga ; Rudan, Igor ; Campbe, Harry ; Hayward, Caroline ; Wright, Alan ; Kolčić, Ivana ; O'Donoghue, Niaobh ; Bones, Jonathan ; Rudd, Pauline M. ; Lauc, Gordan

Izvornik
Journal of proteome research (1535-3893) 8 (2009), 2; 694-701

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Human plasma glycome; N-glycosylation; glycan analysis; variability of glycans; heritability of glycans; age-dependant changes

Sažetak
Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently-labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom (Gordan Lauc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Medicinski fakultet, Osijek,
GENOS d.o.o.

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati