Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome (CROSBI ID 147354)
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Podaci o odgovornosti
Knežević, Ana ; Polašek, Ozren ; Gornik, Olga ; Rudan, Igor ; Campbe, Harry ; Hayward, Caroline ; Wright, Alan ; Kolčić, Ivana ; O'Donoghue, Niaobh ; Bones, Jonathan ; Rudd, Pauline M. ; Lauc, Gordan
engleski
Variability, Heritability and Environmental Determinants of Human Plasma N-Glycome
Plasma glycans were analyzed in 1008 individuals to evaluate variability and heritability, as well as the main environmental determinants that affect glycan structures. By combining HPLC analysis of fluorescently-labeled glycans with sialidase digestion, glycans were separated into 33 chromatographic peaks and quantified. A high level of variability was observed with the median ratio of minimal to maximal values of 6.17 and significant age- and gender-specific differences. Heritability estimates for individual glycans varied widely, ranging from very low to very high. Glycome-wide environmental determinants were also detected with statistically significant effects of different variables including diet, smoking and cholesterol levels.
human plasma glycome; N-glycosylation; glycan analysis; variability of glycans; heritability of glycans; age-dependant changes
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Biologija