engleski

Subchronic Oral Exposure to Prometryne Changes Relations of Blood Biochemistry Parameters in Mice

Prometryne is a methylthio-s-triazine herbicide used for control of annual broadleaf and grass weeds in many cultivated plants. Significant traces are documented in environment, mainly waters, soil and plants used for human and domestic animal nutrition. The aim of this study was to investigate whether prometryne, applied orally, could induce changes in metabolic patterns and cause cell damage in specific organs of exposed mice. Three different doses of prometryne (185, 375, 555 mg kg-1) were applied per os repeatedly every 48 hour, in a subchronic in vivo experimental design. After 28th days (14 doses), the correlations between the basic blood biochemistry parameters were analyzed (LDH, GGT, AlP, creatinine, ALT, AST). The increase in GGT and decrease in creatinine were the most distinct effects. LDH and AlP were increased, but rather explicitly in different dosage groups. ALT and AST did not change significantly, which indicate that liver damage was less then expected. Significant correlations between renal tissue specific enzymes were lost in exposed groups. The correlations between muscle tissue specific enzymes were significant as a result prometryne toxicity.

prometryne; nephrotoxicity; myotoxicity; hepatotoxicity; CBA

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