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Pregled bibliografske jedinice broj: 38046

Medullary thyroid carcinoma

Dabelić, Nina; Mateša, Neven; Gall-Trošelj, Koraljka; Krušlin, Božo; Pavelić, Jasminka; Pavelić, Krešimir; Kusić, Zvonko
Medullary thyroid carcinoma // Acta Clinica Croatica, 38 (1999), 4; 227-239 (međunarodna recenzija, članak, znanstveni)

Medullary thyroid carcinoma
(Madullary thyroid carcinoma)

Dabelić, Nina ; Mateša, Neven ; Gall-Trošelj, Koraljka ; Krušlin, Božo ; Pavelić, Jasminka ; Pavelić, Krešimir ; Kusić, Zvonko

Acta Clinica Croatica (0353-9466) 38 (1999), 4; 227-239

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Medullary thyroid carcinoma; sporadic; familial; multiple endocrine neoplasia type 2 syndrome; calcitonin specific tumor marker; ret proto-oncogene

Medullary thyroid carcinoma (MTC) is an uncommon thyroid tumor accounting for only 3%-5% of all thyroid malignancies. Nevertheless, it has attracted a great deal of interest for its distinctive biochemical and genetic features and unique clinical associations, with a predilection for early diagnosis and an appropriate surgical approach. In this paper, we review these features, including the four distinct clinical forms of MTC: sporadic MTC, familial MTC (FMTC), and multiple endocrine neoplasia 2A and 2B syndromes. We also review the role of serum calcitonin levels as a specific tumor marker in this carcinoma. Special emphasis is put on the recent key advances that have clarified the genetic basis of MTC and now hold tremendous promise for improving the diagnosis and treatment of this cancer. In addition, we give an overview of our clinical experience with a total of 33 patients we have encountered during a 20-year period at the Department of Oncology and Nuclear medicine, Sestre milosrdnice University Hospital.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita


Projekt / tema

Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"

Časopis indeksira:

  • Scopus

Uključenost u ostale bibliografske baze podataka:

  • Excerpta Medica